Interferon receptor

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== Relevance ==
== Relevance ==
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Lack of neuronal interferon α/β receptor causes Lewy Body and Parkinson-like dementia in mice<ref>PMID:16451483</ref>.
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Lack of neuronal interferon α/β receptor causes Lewy Body and Parkinson-like dementia in mice<ref>PMID:16451483</ref>. Interferon α/β receptor deficiency has a role in the pathogenesis of lupus<ref>PMID:12642605</ref>.
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== Disease ==
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Mutations of interferon γ receptor confer susceptibility to infections caused by mycobacteria<ref>PMID:10192386</ref>.
</StructureSection>
</StructureSection>

Revision as of 07:57, 30 March 2016

Structure of interferon α/β receptor β chain ectodomain (green and yellow) complex with interferon-α 2 (grey and pink) and Cl- ion (green) (PDB entry 3s9d)

Drag the structure with the mouse to rotate

3D structures of interferon receptor

Updated on 30-March-2016

References

  1. ↑ Uze G, Schreiber G, Piehler J, Pellegrini S. The receptor of the type I interferon family. Curr Top Microbiol Immunol. 2007;316:71-95. PMID:17969444
  2. ↑ Pestka S, Kotenko SV, Muthukumaran G, Izotova LS, Cook JR, Garotta G. The interferon gamma (IFN-gamma) receptor: a paradigm for the multichain cytokine receptor. Cytokine Growth Factor Rev. 1997 Sep;8(3):189-206. PMID:9462485
  3. ↑ Lefevre F, Guillomot M, D'Andrea S, Battegay S, La Bonnardiere C. Interferon-delta: the first member of a novel type I interferon family. Biochimie. 1998 Aug-Sep;80(8-9):779-88. PMID:9865499
  4. ↑ . PMID:16451483
  5. ↑ Santiago-Raber ML, Baccala R, Haraldsson KM, Choubey D, Stewart TA, Kono DH, Theofilopoulos AN. Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice. J Exp Med. 2003 Mar 17;197(6):777-88. PMID:12642605 doi:http://dx.doi.org/10.1084/jem.20021996
  6. ↑ Jouanguy E, Lamhamedi-Cherradi S, Lammas D, Dorman SE, Fondaneche MC, Dupuis S, Doffinger R, Altare F, Girdlestone J, Emile JF, Ducoulombier H, Edgar D, Clarke J, Oxelius VA, Brai M, Novelli V, Heyne K, Fischer A, Holland SM, Kumararatne DS, Schreiber RD, Casanova JL. A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. Nat Genet. 1999 Apr;21(4):370-8. PMID:10192386 doi:http://dx.doi.org/10.1038/7701

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Michal Harel

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