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1h4u
From Proteopedia
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'''DOMAIN G2 OF MOUSE NIDOGEN-1''' | '''DOMAIN G2 OF MOUSE NIDOGEN-1''' | ||
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[[Category: Ries, A.]] | [[Category: Ries, A.]] | ||
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Revision as of 15:25, 2 May 2008
DOMAIN G2 OF MOUSE NIDOGEN-1
Overview
Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. Here, we report the crystal structure of the mouse nidogen-1 G2 fragment, which contains binding sites for collagen IV and perlecan. The structure is composed of an EGF-like domain and an 11-stranded beta-barrel with a central helix. The beta-barrel domain has unexpected similarity to green fluorescent protein. A large surface patch on the beta-barrel is strikingly conserved in all metazoan nidogens. Site-directed mutagenesis demonstrates that the conserved residues are involved in perlecan binding.
About this Structure
1H4U is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1., Hopf M, Gohring W, Ries A, Timpl R, Hohenester E, Nat Struct Biol. 2001 Jul;8(7):634-40. PMID:11427896 Page seeded by OCA on Fri May 2 18:25:52 2008
