1h4u

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{{Structure
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{{STRUCTURE_1h4u| PDB=1h4u | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h4u OCA], [http://www.ebi.ac.uk/pdbsum/1h4u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h4u RCSB]</span>
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'''DOMAIN G2 OF MOUSE NIDOGEN-1'''
'''DOMAIN G2 OF MOUSE NIDOGEN-1'''
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[[Category: Ries, A.]]
[[Category: Ries, A.]]
[[Category: Timpl, R.]]
[[Category: Timpl, R.]]
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[[Category: extracellular matrix protein]]
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[[Category: Extracellular matrix protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:25:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:57:49 2008''
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Revision as of 15:25, 2 May 2008

Image:1h4u.gif

Template:STRUCTURE 1h4u

DOMAIN G2 OF MOUSE NIDOGEN-1


Overview

Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. Here, we report the crystal structure of the mouse nidogen-1 G2 fragment, which contains binding sites for collagen IV and perlecan. The structure is composed of an EGF-like domain and an 11-stranded beta-barrel with a central helix. The beta-barrel domain has unexpected similarity to green fluorescent protein. A large surface patch on the beta-barrel is strikingly conserved in all metazoan nidogens. Site-directed mutagenesis demonstrates that the conserved residues are involved in perlecan binding.

About this Structure

1H4U is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1., Hopf M, Gohring W, Ries A, Timpl R, Hohenester E, Nat Struct Biol. 2001 Jul;8(7):634-40. PMID:11427896 Page seeded by OCA on Fri May 2 18:25:52 2008

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