1h5c

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[[Image:1h5c.jpg|left|200px]]
[[Image:1h5c.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1h5c |SIZE=350|CAPTION= <scene name='initialview01'>1h5c</scene>, resolution 1.62&Aring;
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The line below this paragraph, containing "STRUCTURE_1h5c", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CAA:Hem+Binding+Site+For+Chain+A'>CAA</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1h5c| PDB=1h5c | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h5c OCA], [http://www.ebi.ac.uk/pdbsum/1h5c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h5c RCSB]</span>
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}}
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'''X-RAY INDUCED REDUCTION OF HORSERADISH PEROXIDASE C1A COMPOUND III (100-200% DOSE)'''
'''X-RAY INDUCED REDUCTION OF HORSERADISH PEROXIDASE C1A COMPOUND III (100-200% DOSE)'''
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[[Category: Smith, A T.]]
[[Category: Smith, A T.]]
[[Category: Szoke, H.]]
[[Category: Szoke, H.]]
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[[Category: compound iii]]
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[[Category: Compound iii]]
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[[Category: horseradish]]
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[[Category: Horseradish]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: oxyperoxidase]]
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[[Category: Oxyperoxidase]]
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[[Category: peroxidase]]
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[[Category: Peroxidase]]
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[[Category: x-ray induced reduction]]
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[[Category: X-ray induced reduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:27:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:58:02 2008''
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Revision as of 15:27, 2 May 2008

Image:1h5c.jpg

Template:STRUCTURE 1h5c

X-RAY INDUCED REDUCTION OF HORSERADISH PEROXIDASE C1A COMPOUND III (100-200% DOSE)


Overview

A molecular description of oxygen and peroxide activation in biological systems is difficult, because electrons liberated during X-ray data collection reduce the active centres of redox enzymes catalysing these reactions. Here we describe an effective strategy to obtain crystal structures for high-valency redox intermediates and present a three-dimensional movie of the X-ray-driven catalytic reduction of a bound dioxygen species in horseradish peroxidase (HRP). We also describe separate experiments in which high-resolution structures could be obtained for all five oxidation states of HRP, showing such structures with preserved redox states for the first time.

About this Structure

1H5C is a Single protein structure of sequence from Armoracia rusticana. Full crystallographic information is available from OCA.

Reference

The catalytic pathway of horseradish peroxidase at high resolution., Berglund GI, Carlsson GH, Smith AT, Szoke H, Henriksen A, Hajdu J, Nature. 2002 May 23;417(6887):463-8. PMID:12024218 Page seeded by OCA on Fri May 2 18:27:08 2008

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