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Ire1

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== Structural highlights ==
== Structural highlights ==
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Yeast Ire1 structure shows a different binding site for ADP and for quercetin. Quercetin is a powerful activator of Ire1. Ire1 binds 2 molecules of quercetin at its dimer interface<ref>PMID:23880584</ref>.
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Yeast Ire1 structure contains 3 phosphorylated residues: 2 Ser and a Thr. It and shows a different binding site for ADP and for quercetin. Quercetin is a powerful activator of Ire1. Ire1 binds 2 molecules of quercetin at its dimer interface<ref>PMID:23880584</ref>.
==3D structures of Ire1==
==3D structures of Ire1==

Revision as of 07:33, 3 April 2016

Structure of yeast Ire1 cytoplasmic domain dimer complex with quercetin, ADP (stick model), Ca+2 and Sr+2 ions (PDB entry 3lj0)

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Michal Harel, Alexander Berchansky

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