Kallikrein
From Proteopedia
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== Function == | == Function == | ||
| - | '''Kallikrein''' (KLK) is a serine protease. Plasma KLK releases the peptides bradykinin and kallidin from kininogen and plasmin from plasminogen. Tissue KLK participates in the regulation of blood pressure by activation of bradykinin<ref>PMID:19689262</ref>. | + | '''Kallikrein''' (KLK) is a serine protease. Plasma KLK releases the peptides bradykinin and kallidin from kininogen and plasmin from plasminogen. Tissue KLK participates in the regulation of blood pressure by activation of bradykinin<ref>PMID:19689262</ref>.<br /> |
| + | *'''KLK1''' releases the vasoactive peptide Lys-bradikinin from kininogen.<br /> | ||
| + | *'''KLK2''' is prostate-specific.<br /> | ||
| + | *'''KLK4''' cleaves extracellular matrix proteins.<br /> | ||
| + | *'''KLK5''' and '''KLK7''' regulate cell shedding.<br /> | ||
| + | *'''KLK6''' regulates immune cells survival.<br /> | ||
== Disease == | == Disease == | ||
| - | Activation of the plasma KLK pathway may contribute to diabetic macular edema<ref>PMID:20535647</ref>. | + | Activation of the plasma KLK pathway may contribute to diabetic macular edema<ref>PMID:20535647</ref>. KLK6 is implicated in carcinogenesis, Alzheimer and Parkinson diseases<ref>PMID:16800739</ref>.<br />. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 07:54, 6 April 2016
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3D Structures of kallikrein
Updated on 06-April-2016
References
- ↑ Bryant JW, Shariat-Madar Z. Human plasma kallikrein-kinin system: physiological and biochemical parameters. Cardiovasc Hematol Agents Med Chem. 2009 Jul;7(3):234-50. PMID:19689262
- ↑ Feener EP. Plasma kallikrein and diabetic macular edema. Curr Diab Rep. 2010 Aug;10(4):270-5. doi: 10.1007/s11892-010-0127-1. PMID:20535647 doi:http://dx.doi.org/10.1007/s11892-010-0127-1
- ↑ Pampalakis G, Sotiropoulou G. Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. Biol Chem. 2006 Jun;387(6):773-82. PMID:16800739 doi:http://dx.doi.org/10.1515/BC.2006.097
- ↑ Debela M, Magdolen V, Grimminger V, Sommerhoff C, Messerschmidt A, Huber R, Friedrich R, Bode W, Goettig P. Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site. J Mol Biol. 2006 Oct 6;362(5):1094-107. Epub 2006 Aug 3. PMID:16950394 doi:10.1016/j.jmb.2006.08.003
