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Ketohexokinase

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<StructureSection load='3q92' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''>
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<StructureSection load='3q92' size='350' side='right' caption='Human ketohexokinase complex with ihibitor and sulfate (PDB entry [[3q92]])' scene=''>
== Function ==
== Function ==
'''Ketohexokinase''' (KHK) also known as hepatic fructokinase catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in the liver. The HKH gene is spliced to HKH-A and the more active HKH-C. KHK acts in the first step of fructose metabolism<ref>PMID:2996495</ref>.
'''Ketohexokinase''' (KHK) also known as hepatic fructokinase catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in the liver. The HKH gene is spliced to HKH-A and the more active HKH-C. KHK acts in the first step of fructose metabolism<ref>PMID:2996495</ref>.
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== Structural highlights ==
== Structural highlights ==
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<ref>PMID:8528769</ref>
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Human KHK inhibitor interacts with the 2 monomers<ref>PMID:24900346</ref>
</StructureSection>
</StructureSection>
==3D structuresm of ketohexokinase==
==3D structuresm of ketohexokinase==

Revision as of 09:42, 6 April 2016

Human ketohexokinase complex with ihibitor and sulfate (PDB entry 3q92)

Drag the structure with the mouse to rotate

3D structuresm of ketohexokinase

2hlz, 2hqq, 3b3l – hKHK – human
2hw1, 3nbv – hKHK + AMPPNP + fructose
3nbw – hKHK + pyrazole derivative
3nc2, 3nc9, 3nca, 3ro4, 3q92, 3qa2, 3qai – hKHK + inhibitor

References

  1. ↑ Bais R, James HM, Rofe AM, Conyers RA. The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol. Biochem J. 1985 Aug 15;230(1):53-60. PMID:2996495
  2. ↑ Asipu A, Hayward BE, O'Reilly J, Bonthron DT. Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria. Diabetes. 2003 Sep;52(9):2426-32. PMID:12941785
  3. ↑ Maryanoff BE, O'Neill JC, McComsey DF, Yabut SC, Luci DK, Jordan AD Jr, Masucci JA, Jones WJ, Abad MC, Gibbs AC, Petrounia I. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43. doi: 10.1021/ml200070g. eCollection, 2011 Jul 14. PMID:24900346 doi:http://dx.doi.org/10.1021/ml200070g

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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