Kinesin
From Proteopedia
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== Function == | == Function == | ||
| - | [[Kinesin|Kinesins]] are eukaryotic motor proteins which move along microtubules. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition.<br /> | + | [[Kinesin|Kinesins]] are eukaryotic motor proteins which move along microtubules<ref>PMID:19773780</ref>. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition.<br /> |
*'''Kar3''' is kinesin protein in yeast.<br /> | *'''Kar3''' is kinesin protein in yeast.<br /> | ||
*'''Eg5''' or '''KIF11''' is a kinesin (See [[Kinesin-5]]) which participates in mitosis.<br /> | *'''Eg5''' or '''KIF11''' is a kinesin (See [[Kinesin-5]]) which participates in mitosis.<br /> | ||
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**[[1f9t]], [[1f9u]], [[1f9v]], [[1f9w]], [[3kar]] - Kar3 MD (mutant) - yeast<br /> | **[[1f9t]], [[1f9u]], [[1f9v]], [[1f9w]], [[3kar]] - Kar3 MD (mutant) - yeast<br /> | ||
**[[3l1c]] – DmNCD (mutant) | **[[3l1c]] – DmNCD (mutant) | ||
| - | |||
| - | *KCBP | ||
| - | |||
| - | **[[3h4s]] – KCBP+ADP+Mg – ''Arabidopsis thaliana''<br /> | ||
*NOD | *NOD | ||
Revision as of 06:25, 7 April 2016
Function
Kinesins are eukaryotic motor proteins which move along microtubules[1]. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition.
- Kar3 is kinesin protein in yeast.
- Eg5 or KIF11 is a kinesin (See Kinesin-5) which participates in mitosis.
- KCBP is a Kinesin-like Calmodulin Binding Protein.
- NOD is a Drosophila chromosome-associated kinesin.
See also CAP-Gly domain.
3D Structures of Kinesin
Updated on 07-April-2016
References
- ↑ Hirokawa N, Noda Y, Tanaka Y, Niwa S. Kinesin superfamily motor proteins and intracellular transport. Nat Rev Mol Cell Biol. 2009 Oct;10(10):682-96. doi: 10.1038/nrm2774. PMID:19773780 doi:http://dx.doi.org/10.1038/nrm2774
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