Janus kinase
From Proteopedia
(Difference between revisions)
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *JAK1 | + | *JAK1 kinase domain |
| + | |||
| + | **[[4e4l]], [[4e4n]], [[4e5w]], [[4ehz]], [[4ei4]], [[4fk6]], [[4i5c]], [[4k6z]], [[3eyg]], [[3eyh]], [[5e1e]], [[5hx8]], [[5khx]] – hJAK1 kinase domain + PTyr + inhibitor - human<br /> | ||
| + | **[[5khw]] – hJAK1 kinase domain + PTyr + ADP<br /> | ||
| + | |||
| + | *JAK1 JH1 domain | ||
| - | **[[4e4l]], [[4e4n]], [[4e5w]], [[4ehz]], [[4ei4]], [[4fk6]], [[4i5c]], [[4k6z]], [[3eyg]], [[3eyh]] – hJAK1 kinase domain + PTyr + inhibitor - human<br /> | ||
**[[4k77]] – hJAK1 JH1 domain + PTyr + inhibitor <br /> | **[[4k77]] – hJAK1 JH1 domain + PTyr + inhibitor <br /> | ||
| + | |||
| + | *JAK1 pseudokinase domain | ||
**[[4l00]] – hJAK1 pseudokinase domain <br /> | **[[4l00]] – hJAK1 pseudokinase domain <br /> | ||
**[[4l01]] – hJAK1 pseudokinase domain (mutant)<br /> | **[[4l01]] – hJAK1 pseudokinase domain (mutant)<br /> | ||
| + | |||
| + | *JAK1 FERM-SH2 domain | ||
| + | |||
| + | **[[5ixd]], [[5l04]] – hJAK1 + IFN l receptor <br /> | ||
| + | **[[5ixi]] – hJAK1 + IFN l receptor/IL10 <br /> | ||
*JAK2 kinase domain | *JAK2 kinase domain | ||
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**[[4fvp]] - hJAK2 kinase domain <br /> | **[[4fvp]] - hJAK2 kinase domain <br /> | ||
**[[2b7a]], [[3fup]], [[4e6d]], [[4e6q]], [[4f08]] – hJAK2 kinase domain (mutant) + PTyr + inhibitor <br /> | **[[2b7a]], [[3fup]], [[4e6d]], [[4e6q]], [[4f08]] – hJAK2 kinase domain (mutant) + PTyr + inhibitor <br /> | ||
| - | **[[3ugc]], [[4bbe]], [[4bbf]], [[3zmm]], [[2xa4]], [[4c61]], [[4c62]] – hJAK2 kinase domain (mutant) + inhibitor <br /> | + | **[[3ugc]], [[4bbe]], [[4bbf]], [[3zmm]], [[2xa4]], [[4c61]], [[4c62]], [[5l3a]], [[5tq3]], [[5tq4]], [[5tq5]], [[5tq6]], [[5tq7]], [[5tq8]] – hJAK2 kinase domain (mutant) + inhibitor <br /> |
| - | **[[3e62]], [[3e63]], [[3e64]], [[2w1i]], [[ | + | **[[3e62]], [[3e63]], [[3e64]], [[2w1i]], [[3i[[4ytc]], [[4ytf]], [[4yth]], [[4yti]], [[4zim]], [[5aep]], [[5cf4]], [[5cf5]], [[5cf6]], [[5cf8]]o7]], [[3iok]], [[3kck]], [[3jy9]], [[3lpb]], [[3krr]], [[3q32]], [[3tjc]], [[3tjd]], [[3rvg]], [[4aqc]], [[4e4m]], [[4f09]], [[4hge]], [[4d0w]], [[4d0x]], [[4d1s]], [[4p7e]], [[4aep]], [[4ytc]], [[4ytf]], [[4yth]], [[4yti]], [[4zim]], [[5aep]], [[5cf4]], [[5cf5]], [[5cf6]], [[5cf8]] – hJAK2 kinase domain + PTyr + inhibitor <br /> |
**[[4gl9]] – mJAK2 kinase domain + PTyr + inhibitor + suppressor of cytokine signaling 3 + interleukin 6 receptor subunit β - mouse<br /> | **[[4gl9]] – mJAK2 kinase domain + PTyr + inhibitor + suppressor of cytokine signaling 3 + interleukin 6 receptor subunit β - mouse<br /> | ||
*JAK2 JH1 domain | *JAK2 JH1 domain | ||
| - | **[[4gfm]], [[4gmy]], [[4iva]], [[4ivb]], [[4ivc]], [[4ivd]], [[4ji9]], [[4jia]] - hJAK2 JH1 domain + PTyr + inhibitor <br /> | + | **[[4gfm]], [[4gmy]], [[4iva]], [[4ivb]], [[4ivc]], [[4ivd]], [[4ji9]], [[4jia]], [[5usy]], [[5usz]], [[5ut0]], [[5ut1]], [[5ut2]], [[5ut3]], [[5ut4]], [[5ut5]], [[5ut6]] - hJAK2 JH1 domain + PTyr + inhibitor <br /> |
| + | **[[5hez]] - hJAK2 JH1 domain (mutant) + PTyr + inhibitor <br /> | ||
*JAK2 pseudokinase domain | *JAK2 pseudokinase domain | ||
**[[3ugc]] – hJAK2 pseudokinase domain (mutant) <br /> | **[[3ugc]] – hJAK2 pseudokinase domain (mutant) <br /> | ||
| - | **[[4fvq]], [[4fvr]] – hJAK2 pseudokinase domain (mutant) + ATP<br /> | + | **[[4fvq]], [[4fvr]], [[5i4n]] – hJAK2 pseudokinase domain (mutant) + ATP<br /> |
| + | |||
| + | *JAK2 FERM-SH2 domain | ||
| + | |||
| + | **[[4z32]] – hJAK2 <br /> | ||
*JAK3 kinase domain | *JAK3 kinase domain | ||
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**[[1yvj]] – hJAK3 kinase domain (mutant) + PTyr + staurosporine analog<br /> | **[[1yvj]] – hJAK3 kinase domain (mutant) + PTyr + staurosporine analog<br /> | ||
**[[3lxk]], [[3lxl]] – hJAK3 kinase domain (mutant) + PTyr + inhibitor <br /> | **[[3lxk]], [[3lxl]] – hJAK3 kinase domain (mutant) + PTyr + inhibitor <br /> | ||
| - | **[[3pjc]] – hJAK3 kinase domain + inhibitor <br /> | + | **[[3pjc]], [[4v0g]], [[4z16]], [[5lwm]], [[5lwn]], [[5toz]] – hJAK3 kinase domain + inhibitor <br /> |
| - | **[[4hvd]], [[4hvg]], [[4hvh]], [[4hvi]], [[3zc6]], [[3zep]], [[4i6q]], [[4qps]], [[4rio]] – hJAK3 kinase domain (mutant) + inhibitor <br /> | + | **[[4hvd]], [[4hvg]], [[4hvh]], [[4hvi]], [[3zc6]], [[3zep]], [[4i6q]], [[4qps]], [[4rio]], [[4qt1]], [[5tts]], [[5ttu]], [[5ttv]], [[5vo6]] – hJAK3 kinase domain (mutant) + inhibitor <br /> |
*TYK2 see [[Tyrosine kinase]] | *TYK2 see [[Tyrosine kinase]] | ||
Revision as of 10:56, 25 June 2017
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3D Structures of Janus kinase
Updated on 25-June-2017
References
- ↑ Liu KD, Gaffen SL, Goldsmith MA, Greene WC. Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation. Curr Biol. 1997 Nov 1;7(11):817-26. PMID:9382798
- ↑ O'Shea JJ, Kontzias A, Yamaoka K, Tanaka Y, Laurence A. Janus kinase inhibitors in autoimmune diseases. Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii111-5. doi: 10.1136/annrheumdis-2012-202576. PMID:23532440 doi:http://dx.doi.org/10.1136/annrheumdis-2012-202576
- ↑ Levine RL. Janus kinase mutations. Semin Oncol. 2009 Apr;36(2 Suppl 1):S6-11. doi: 10.1053/j.seminoncol.2009.02.005. PMID:19393837 doi:http://dx.doi.org/10.1053/j.seminoncol.2009.02.005
- ↑ Schenkel LB, Huang X, Cheng A, Deak HL, Doherty E, Emkey R, Gu Y, Gunaydin H, Kim JL, Lee J, Loberg R, Olivieri P, Pistillo J, Tang J, Wan Q, Wang HL, Wang SW, Wells MC, Wu B, Yu V, Liu L, Geuns-Meyer S. Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 Inhibitors. J Med Chem. 2011 Nov 16. PMID:22087750 doi:10.1021/jm200911r
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