Sandbox Reserved 431
From Proteopedia
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==Binding Interactions== | ==Binding Interactions== | ||
| - | <scene name='48/483888/Spacefilled_binding_site/1'>Space filling representation | + | The binding of Vitamin D3 occurs in a channel between the G and I helices and B' helix and B-C loop. In the <scene name='48/483888/Spacefilled_binding_site/1'>Space filling representation </scene> you can see the residues that interact to bind Vitamin D3 and the channel between. Most of these residues are hydrophobic and thus have non polar interactions. Binding of the substrate causes the access channel to close. The B' helix has a flexible C terminus and can adopt a helix or loop conformation, which has van der waal interactions with the F-G loop. The B' helix unwinds outward to allow entrance of the substrate into the active site channel. CYP2R1 has an extended binding site where the access channel is part of the active site. |
-catalyzes initial step for converting vitamin D into 25-hydroxyvitamin D | -catalyzes initial step for converting vitamin D into 25-hydroxyvitamin D | ||
-mutation causes rickets-25-hydroxylase deficiency | -mutation causes rickets-25-hydroxylase deficiency | ||
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Revision as of 15:37, 7 April 2016
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Vitamin D activation by cytochrome P450, Rickets (3c6g)[1]
by Isabel Hand, Elizabeth Humble, Kati Johnson, Samantha Kriksceonaitis, and Matthew Tiller
Student Projects for UMass Chemistry 423 Spring 2016
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