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1h6i

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[[Image:1h6i.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1h6i| PDB=1h6i | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h6i OCA], [http://www.ebi.ac.uk/pdbsum/1h6i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h6i RCSB]</span>
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'''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1'''
'''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1'''
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[[Category: Groot, B L.De.]]
[[Category: Groot, B L.De.]]
[[Category: Grubmuller, H.]]
[[Category: Grubmuller, H.]]
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[[Category: electron diffraction]]
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[[Category: Electron diffraction]]
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[[Category: electron microscopy]]
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[[Category: Electron microscopy]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: two-dimensional crystal]]
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[[Category: Two-dimensional crystal]]
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[[Category: water channel]]
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[[Category: Water channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:29:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:58:46 2008''
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Revision as of 15:29, 2 May 2008

Image:1h6i.gif

Template:STRUCTURE 1h6i

A REFINED STRUCTURE OF HUMAN AQUAPORIN 1


Overview

A refined structure of the human water channel aquaporin-1 is presented. The model rests on the high resolution X-ray structure of the homologous bacterial glycerol transporter GlpF, electron crystallographic data at 3.8 A resolution and a multiple sequence alignment of the aquaporin superfamily. The crystallographic R and free R values (36.7% and 37.8%) for the refined structure are significantly lower than for previous models. Improved geometry and enhanced stability in molecular dynamics simulations demonstrate a significant improvement of the aquaporin-1 structure. Comparison with previous aquaporin-1 models shows significant differences, not only in the loop regions, but also in the core of the water channel.

About this Structure

1H6I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:11532455 Page seeded by OCA on Fri May 2 18:29:42 2008

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