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1h8f

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[[Image:1h8f.gif|left|200px]]
[[Image:1h8f.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1h8f |SIZE=350|CAPTION= <scene name='initialview01'>1h8f</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1h8f", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Epe+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1h8f| PDB=1h8f | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8f OCA], [http://www.ebi.ac.uk/pdbsum/1h8f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h8f RCSB]</span>
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}}
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'''GLYCOGEN SYNTHASE KINASE 3 BETA.'''
'''GLYCOGEN SYNTHASE KINASE 3 BETA.'''
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[[Category: Pearl, L H.]]
[[Category: Pearl, L H.]]
[[Category: Roe, S M.]]
[[Category: Roe, S M.]]
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[[Category: insulin pathway]]
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[[Category: Insulin pathway]]
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[[Category: kinase]]
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[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:34:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:59:55 2008''
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Revision as of 15:34, 2 May 2008

Image:1h8f.gif


PDB ID 1h8f

Drag the structure with the mouse to rotate
1h8f, resolution 2.80Å ()
Ligands:
Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



GLYCOGEN SYNTHASE KINASE 3 BETA.


Overview

Glycogen synthase kinase 3 beta (GSK3 beta) plays a key role in insulin and Wnt signaling, phosphorylating downstream targets by default, and becoming inhibited following the extracellular signaling event. The crystal structure of human GSK3 beta shows a catalytically active conformation in the absence of activation-segment phosphorylation, with the sulphonate of a buffer molecule bridging the activation-segment and N-terminal domain in the same way as the phosphate group of the activation-segment phospho-Ser/Thr in other kinases. The location of this oxyanion binding site in the substrate binding cleft indicates direct coupling of P+4 phosphate-primed substrate binding and catalytic activation, explains the ability of GSK3 beta to processively hyperphosphorylate substrates with Ser/Thr pentad-repeats, and suggests a mechanism for autoinhibition in which the phosphorylated N terminus binds as a competitive pseudosubstrate with phospho-Ser 9 occupying the P+4 site.

About this Structure

1H8F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition., Dajani R, Fraser E, Roe SM, Young N, Good V, Dale TC, Pearl LH, Cell. 2001 Jun 15;105(6):721-32. PMID:11440715 Page seeded by OCA on Fri May 2 18:34:04 2008

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