1h8e

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[[Image:1h8e.gif|left|200px]]
[[Image:1h8e.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1h8e |SIZE=350|CAPTION= <scene name='initialview01'>1h8e</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1h8e", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Adp+Binding+Site+For+Chain+B'>AC3</scene>, <scene name='pdbsite=AC4:Mg+Binding+Site+For+Chain+B'>AC4</scene>, <scene name='pdbsite=AC5:Adp+Binding+Site+For+Chain+C'>AC5</scene>, <scene name='pdbsite=AC6:Mg+Binding+Site+For+Chain+C'>AC6</scene>, <scene name='pdbsite=AC7:Adp+Binding+Site+For+Chain+D'>AC7</scene>, <scene name='pdbsite=AC8:Mg+Binding+Site+For+Chain+D'>AC8</scene>, <scene name='pdbsite=AC9:Alf+Binding+Site+For+Chain+D'>AC9</scene>, <scene name='pdbsite=BC1:Adp+Binding+Site+For+Chain+E'>BC1</scene>, <scene name='pdbsite=BC2:Mg+Binding+Site+For+Chain+E'>BC2</scene>, <scene name='pdbsite=BC3:So4+Binding+Site+For+Chain+E'>BC3</scene>, <scene name='pdbsite=BC4:Adp+Binding+Site+For+Chain+F'>BC4</scene>, <scene name='pdbsite=BC5:Mg+Binding+Site+For+Chain+F'>BC5</scene>, <scene name='pdbsite=BC6:Alf+Binding+Site+For+Chain+F'>BC6</scene>, <scene name='pdbsite=CAT:The+Carboxylate+Group+Of+GLU+Residue+Is+Believed+To+Acti+...'>CAT</scene> and <scene name='pdbsite=PLP:LYS+Within+The+P-Loop+(Phosphate+Bindi+Motif,+Gxxxxgkt/S'>PLP</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1h8e| PDB=1h8e | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8e OCA], [http://www.ebi.ac.uk/pdbsum/1h8e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h8e RCSB]</span>
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}}
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'''(ADP.ALF4)2(ADP.SO4) BOVINE F1-ATPASE (ALL THREE CATALYTIC SITES OCCUPIED)'''
'''(ADP.ALF4)2(ADP.SO4) BOVINE F1-ATPASE (ALL THREE CATALYTIC SITES OCCUPIED)'''
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Structure of bovine mitochondrial F(1)-ATPase with nucleotide bound to all three catalytic sites: implications for the mechanism of rotary catalysis., Menz RI, Walker JE, Leslie AG, Cell. 2001 Aug 10;106(3):331-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11509182 11509182]
Structure of bovine mitochondrial F(1)-ATPase with nucleotide bound to all three catalytic sites: implications for the mechanism of rotary catalysis., Menz RI, Walker JE, Leslie AG, Cell. 2001 Aug 10;106(3):331-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11509182 11509182]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: H(+)-transporting two-sector ATPase]]
 
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Leslie, A G.W.]]
[[Category: Leslie, A G.W.]]
[[Category: Menz, R I.]]
[[Category: Menz, R I.]]
[[Category: Walker, J E.]]
[[Category: Walker, J E.]]
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[[Category: atp phosphorylase]]
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[[Category: Atp phosphorylase]]
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[[Category: atp phosphorylase (h+ transporting)]]
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[[Category: Atp synthase]]
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[[Category: atp synthase]]
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[[Category: F1-atpase]]
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[[Category: f1-atpase]]
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[[Category: F1fo atp synthase]]
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[[Category: f1fo atp synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:34:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:59:56 2008''
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Revision as of 15:34, 2 May 2008

Image:1h8e.gif

Template:STRUCTURE 1h8e

(ADP.ALF4)2(ADP.SO4) BOVINE F1-ATPASE (ALL THREE CATALYTIC SITES OCCUPIED)


Overview

The crystal structure of a novel aluminium fluoride inhibited form of bovine mitochondrial F(1)-ATPase has been determined at 2 A resolution. In contrast to all previously determined structures of the bovine enzyme, all three catalytic sites are occupied by nucleotide. The subunit that did not bind nucleotide in previous structures binds ADP and sulfate (mimicking phosphate), and adopts a "half-closed" conformation. This structure probably represents the posthydrolysis, pre-product release step on the catalytic pathway. A catalytic scheme for hydrolysis (and synthesis) at physiological rates and a mechanism for the ATP-driven rotation of the gamma subunit are proposed based on the crystal structures of the bovine enzyme.

About this Structure

1H8E is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of bovine mitochondrial F(1)-ATPase with nucleotide bound to all three catalytic sites: implications for the mechanism of rotary catalysis., Menz RI, Walker JE, Leslie AG, Cell. 2001 Aug 10;106(3):331-41. PMID:11509182 Page seeded by OCA on Fri May 2 18:34:02 2008

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