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Isopropylmalate dehydrogenase

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<scene name='49/490899/Cv/2'>3-isopropylmalate dehydrogenase complex with 3-isopropylmalate, glycerol, NAD, PMSF, Mn+2 and K- ions</scene>.
<scene name='49/490899/Cv/2'>3-isopropylmalate dehydrogenase complex with 3-isopropylmalate, glycerol, NAD, PMSF, Mn+2 and K- ions</scene>.
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IMDH active site containing the NAD cofactor is located between 2 subunits and contains the substrate and Mn+2 and K- ions<ref>PMID:25211160</ref>.
+
IMDH active site containing the <scene name='49/490899/Cv/9'>NAD cofactor is located between 2 subunits</scene> and contains the substrate and Mn+2 and K- ions<ref>PMID:25211160</ref>. Water molecules shown as red spheres.
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 +
<scene name='49/490899/Cv/4'>MN coordination site</scene>.
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<scene name='49/490899/Cv/6'>K coordination site</scene>.
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<scene name='49/490899/Cv/5'>3-isopropylmalate binding site</scene>.
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<scene name='49/490899/Cv/10'>Whole IMDH active site</scene>.
</StructureSection>
</StructureSection>
==3D structures of isopropylmalate dehydrogenase==
==3D structures of isopropylmalate dehydrogenase==

Revision as of 11:32, 11 April 2016

3-isopropylmalate dehydrogenase complex with 3-isopropylmalate, glycerol, NAD, PMSF, Mn+2 and K- ions (PDB entry 4f7i)

Drag the structure with the mouse to rotate

3D structures of isopropylmalate dehydrogenase

Updated on 11-April-2016

References

  1. ↑ Martignon S, Rossi F, Rizzi M. Expression, purification and characterisation of Haemophilus influenzae 3-isopropylmalate dehydrogenase (LeuB). Protein Pept Lett. 2007;14(8):822-7. PMID:17979826
  2. ↑ Pallo A, Olah J, Graczer E, Merli A, Zavodszky P, Weiss MS, Vas M. Structural and energetic basis of isopropylmalate dehydrogenase enzyme catalysis. FEBS J. 2014 Sep 11. doi: 10.1111/febs.13044. PMID:25211160 doi:http://dx.doi.org/10.1111/febs.13044

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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