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1h9o

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[[Image:1h9o.gif|left|200px]]
[[Image:1h9o.gif|left|200px]]
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{{Structure
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|PDB= 1h9o |SIZE=350|CAPTION= <scene name='initialview01'>1h9o</scene>, resolution 1.79&Aring;
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The line below this paragraph, containing "STRUCTURE_1h9o", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=PTR:Ptr+Binding+Site'>PTR</scene>
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|LIGAND= <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1h9o| PDB=1h9o | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9o OCA], [http://www.ebi.ac.uk/pdbsum/1h9o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h9o RCSB]</span>
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}}
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'''PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A'''
'''PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A'''
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[[Category: Rowsell, S.]]
[[Category: Rowsell, S.]]
[[Category: Weston, S A.]]
[[Category: Weston, S A.]]
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[[Category: complex (phosphotransferase/receptor)]]
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[[Category: Phosphoinositide 3-kinase]]
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[[Category: phosphoinositide 3-kinase]]
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[[Category: Phosphotransferase]]
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[[Category: phosphotransferase]]
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[[Category: Sh2 domain]]
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[[Category: sh2 domain]]
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[[Category: Signal transduction]]
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[[Category: signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:36:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:00:41 2008''
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Revision as of 15:36, 2 May 2008

Image:1h9o.gif

Template:STRUCTURE 1h9o

PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A


Overview

Two cases of successful molecular replacement using NMR trial models are presented. One is the crystal structure of the Escherichia coli colicin immunity protein Im7; the other is a heretofore unreported crystal structure of a specific PDGF receptor-derived peptide complex of the carboxy-terminal SH2 domain from the p85alpha subunit of human phosphatidylinositol 3-OH kinase. In both cases, molecular replacement was non-trivial. Success was achieved using trial models that consisted of an ensemble of NMR structures from which the more flexible portions had been excised. Use of maximum-likelihood refinement proved critical to be able to refine the poor starting models. The challenges typical of the use of NMR trial models in molecular replacement are discussed.

About this Structure

1H9O is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex., Pauptit RA, Dennis CA, Derbyshire DJ, Breeze AL, Weston SA, Rowsell S, Murshudov GN, Acta Crystallogr D Biol Crystallogr. 2001 Oct;57(Pt 10):1397-404. Epub, 2001 Sep 21. PMID:11567151 Page seeded by OCA on Fri May 2 18:36:41 2008

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