Lignin peroxidase

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	== Relevance ==		== Relevance ==
-	Lip is used as a skin-lightening active agent.	+	Lip is used as a skin-lightening active agent<ref>PMID:25574195</ref>.
	==3D structures of lignin peroxidase==		==3D structures of lignin peroxidase==

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Revision as of 08:43, 13 April 2016

Template:STRUCTURE 3q3u

Contents 1 Function 2 Relevance 3 3D structures of lignin peroxidase 4 References

Function

Lignin peroxidase (Lip) catalyzes the biodegradation of lignin using hydrogen peroxide. Lignin comprises 20-30% of woody plants cell wall. It is made of branched and heterogenous structure of phenylpropanoid units. It is highly resistant to biodegradation and only higher fungi are capable of degrading it. Veratryl alcohol is the cofactor in this reaction^[1].

Relevance

Lip is used as a skin-lightening active agent^[2].

3D structures of lignin peroxidase

1lga, 1llp, 1qpa, 1b80, 1b82 – PcLip – Phanerochaete chrysosporium
1b85 – PcLip (mutant)
3q3u – Lip – Trametes cervina

References

1. ↑ Doyle WA, Blodig W, Veitch NC, Piontek K, Smith AT. Two substrate interaction sites in lignin peroxidase revealed by site-directed mutagenesis. Biochemistry. 1998 Oct 27;37(43):15097-105. PMID:9790672 doi:http://dx.doi.org/10.1021/bi981633h
2. ↑ Zhong SM, Sun N, Liu HX, Niu YQ, Wu Y. Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent. Exp Ther Med. 2015 Feb;9(2):341-344. Epub 2014 Dec 8. PMID:25574195 doi:http://dx.doi.org/10.3892/etm.2014.2118