1h9v

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[[Image:1h9v.jpg|left|200px]]
[[Image:1h9v.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1h9v", creates the "Structure Box" on the page.
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{{STRUCTURE_1h9v| PDB=1h9v | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9v OCA], [http://www.ebi.ac.uk/pdbsum/1h9v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h9v RCSB]</span>
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'''HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC'''
'''HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC'''
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[[Category: Kaiser, J.]]
[[Category: Kaiser, J.]]
[[Category: Sondermann, P.]]
[[Category: Sondermann, P.]]
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[[Category: fc-gamma-r]]
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[[Category: Fc-gamma-r]]
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[[Category: fc-receptor]]
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[[Category: Fc-receptor]]
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[[Category: fcgr]]
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[[Category: Fcgr]]
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[[Category: fcr]]
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[[Category: Fcr]]
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[[Category: immunoglobulin]]
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[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:37:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:00:45 2008''
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Revision as of 15:37, 2 May 2008

Image:1h9v.jpg

Template:STRUCTURE 1h9v

HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC


Overview

Once antigen is opsonised by IgG it is removed from the circulation by Fcgamma-receptor expressing cells. Fcgamma-receptors are type I transmembrane molecules that carry extracellular parts consisting of two or three immunoglobulin domains. Previously solved structures of Fc-receptors reveal that the N-terminal two Ig-like domains are arranged in a steep angle forming a heart-shaped structure. The crystal structure of the FcgammaRIII/hIgG1-Fc-fragment demonstrated that the Fc-fragment is recognised through loops of the C-terminal receptor domain of the FcgammaRIII. As the overall structure of the FcRs and their Ig ligands are very similar we modelled the Ig complexes with FcgammaRI, FcgammaRII and FcepsilonRIalpha based on the FcgammaRIII/hIgG1-Fc-fragment structure. The obtained models are consistent with the observed biochemical data and may explain the observed specificity and affinities.

About this Structure

1H9V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular basis for immune complex recognition: a comparison of Fc-receptor structures., Sondermann P, Kaiser J, Jacob U, J Mol Biol. 2001 Jun 8;309(3):737-49. PMID:11397093 Page seeded by OCA on Fri May 2 18:37:05 2008

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