Sandbox WWC2
From Proteopedia
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==Introduction== | ==Introduction== | ||
| - | Monoamine oxidase A (MAO-A) is an flavoenzyme, encoded in the MAOA gene on the X chromosome, present throughout the brain, central nervous system, and stomach | + | Monoamine oxidase A (MAO-A) is an flavoenzyme, encoded in the MAOA gene on the X chromosome, that is present throughout the brain, central nervous system, and stomach. Two isoforms of this enzyme are expressed on the outer surface of the mitochondrial membrane, MAO-A and MAO-B, and both are responsible for the oxidative deamination of various neurotransmitters and dietary amines. Each isoform is characterized by its unique substrate specificity and inhibitor sensitivity (Kaludercic et al.). For example, MAO-A preferentially oxidizes 5-hydroxytryptamine (5-HT), epinephrine, and norepinephrine; while MAO-B prefers phenylethylamine and benzylamine. Both of these enzymes oxidize dopamine, tyramine, and N,N-dimethyltryptamine. |
<Structure load='2Z5X' size='500' frame='top' align='right' caption='Crystal Structure of Human Monoamine Oxidase A with Harmine' scene='Insert optional scene name here' /> | <Structure load='2Z5X' size='500' frame='top' align='right' caption='Crystal Structure of Human Monoamine Oxidase A with Harmine' scene='Insert optional scene name here' /> | ||
Revision as of 20:29, 13 April 2016
Contents |
Introduction
Monoamine oxidase A (MAO-A) is an flavoenzyme, encoded in the MAOA gene on the X chromosome, that is present throughout the brain, central nervous system, and stomach. Two isoforms of this enzyme are expressed on the outer surface of the mitochondrial membrane, MAO-A and MAO-B, and both are responsible for the oxidative deamination of various neurotransmitters and dietary amines. Each isoform is characterized by its unique substrate specificity and inhibitor sensitivity (Kaludercic et al.). For example, MAO-A preferentially oxidizes 5-hydroxytryptamine (5-HT), epinephrine, and norepinephrine; while MAO-B prefers phenylethylamine and benzylamine. Both of these enzymes oxidize dopamine, tyramine, and N,N-dimethyltryptamine.
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The , illustrated in the protein image to the right, in conjunction with the color key, below, indicates the directionality of the polypeptide chain.
| Amino Terminus | Carboxy Terminus |
Function
Disease
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
