Major histocompatibility complex
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='3ox8' size='350' side='right' caption='Human MHC class I complex (grey) with β 2-microglobulin (green), [[2hla]]' scene=''> |
| + | == Function == | ||
''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> | ''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> | ||
* '''MHC class I''' ([[Major Histocompatibility Complex Class I]]) are found in all nucleated cells. These cell surface proteins display peptides from cellular intrinsic proteins<ref>PMID:18675588</ref>. For more details see <br /> | * '''MHC class I''' ([[Major Histocompatibility Complex Class I]]) are found in all nucleated cells. These cell surface proteins display peptides from cellular intrinsic proteins<ref>PMID:18675588</ref>. For more details see <br /> | ||
Revision as of 10:05, 14 April 2016
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3D structures of MHC
Updated on 14-April-2016
References
- ↑ Raghavan M, Del Cid N, Rizvi SM, Peters LR. MHC class I assembly: out and about. Trends Immunol. 2008 Sep;29(9):436-43. doi: 10.1016/j.it.2008.06.004. PMID:18675588 doi:http://dx.doi.org/10.1016/j.it.2008.06.004
- ↑ Holling TM, Schooten E, van Den Elsen PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum Immunol. 2004 Apr;65(4):282-90. PMID:15120183 doi:http://dx.doi.org/10.1016/j.humimm.2004.01.005
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