Major histocompatibility complex
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='3ox8' size='350' side='right' caption='Human MHC class I | + | <StructureSection load='3ox8' size='350' side='right' caption='Human MHC class I antigen (grey, yellow) with β 2-microglobulin (green, magenta) and peptide from pre-core-protein (pink, cyan) [[3ox8]]' scene=''> |
== Function == | == Function == | ||
''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> | ''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> | ||
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*[[MR1 Binds Vitamin Metabolites]].<br /> | *[[MR1 Binds Vitamin Metabolites]].<br /> | ||
* '''MHC class II''' are found in professional antigen-presenting cells like macrophages. These cell surface proteins display peptides from cellular extrinsic proteins<ref>PMID:15120183</ref>. | * '''MHC class II''' are found in professional antigen-presenting cells like macrophages. These cell surface proteins display peptides from cellular extrinsic proteins<ref>PMID:15120183</ref>. | ||
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| + | == Structural highlights == | ||
| + | The peptide derived from Hepatitis virus binds MHC in a peptide-recognition groove and makes various interactions with side chains and with water molecules<ref>PMID:21538979</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:17, 14 April 2016
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3D structures of MHC
Updated on 14-April-2016
References
- ↑ Raghavan M, Del Cid N, Rizvi SM, Peters LR. MHC class I assembly: out and about. Trends Immunol. 2008 Sep;29(9):436-43. doi: 10.1016/j.it.2008.06.004. PMID:18675588 doi:http://dx.doi.org/10.1016/j.it.2008.06.004
- ↑ Holling TM, Schooten E, van Den Elsen PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum Immunol. 2004 Apr;65(4):282-90. PMID:15120183 doi:http://dx.doi.org/10.1016/j.humimm.2004.01.005
- ↑ Liu J, Chen KY, Ren EC. Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: Towards designing better vaccines. Eur J Immunol. 2011 Jul;41(7):2097-106. doi: 10.1002/eji.201041370. PMID:21538979 doi:10.1002/eji.201041370
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