1hbi

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[[Image:1hbi.gif|left|200px]]
[[Image:1hbi.gif|left|200px]]
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{{Structure
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|PDB= 1hbi |SIZE=350|CAPTION= <scene name='initialview01'>1hbi</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1hbi", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>
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{{STRUCTURE_1hbi| PDB=1hbi | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hbi OCA], [http://www.ebi.ac.uk/pdbsum/1hbi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hbi RCSB]</span>
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'''CRYSTAL STRUCTURE OF OXYGENATED SCAPHARCA DIMERIC HEMOGLOBIN AT 1.7 ANGSTROMS RESOLUTION'''
'''CRYSTAL STRUCTURE OF OXYGENATED SCAPHARCA DIMERIC HEMOGLOBIN AT 1.7 ANGSTROMS RESOLUTION'''
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[[Category: Condon, P J.]]
[[Category: Condon, P J.]]
[[Category: Junior, W E.Royer.]]
[[Category: Junior, W E.Royer.]]
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[[Category: oxygen transport]]
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[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:40:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:01:41 2008''
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Revision as of 15:40, 2 May 2008

Template:STRUCTURE 1hbi

CRYSTAL STRUCTURE OF OXYGENATED SCAPHARCA DIMERIC HEMOGLOBIN AT 1.7 ANGSTROMS RESOLUTION


Overview

The crystal structure of the cooperative dimeric hemoglobin from the blood clam Scapharca inaequivalvis has been determined in the oxygenated state and refined to an R-factor of 0.157 at 1.7-A resolution. The structure is very similar to the carbon monoxide-liganded form with subtle differences in ligand binding geometry. Oxygen binds to the heme iron in a bent conformation with Fe-O-O angles of 135 degrees and 150 degrees for the two subunits. These observed angles are lower than the equivalent angles in the carbon monoxide-liganded form and intermediate between the angles observed in structures of oxygenated sperm whale myoglobin and oxygenated human hemoglobin. This third high resolution structure of Scapharca dimeric hemoglobin permits a detailed analysis of the water structure in the highly hydrated interface between subunits.

About this Structure

1HBI is a Single protein structure of sequence from Scapharca inaequivalvis. Full crystallographic information is available from OCA.

Reference

Crystal structure of oxygenated Scapharca dimeric hemoglobin at 1.7-A resolution., Condon PJ, Royer WE Jr, J Biol Chem. 1994 Oct 14;269(41):25259-67. PMID:7929217 Page seeded by OCA on Fri May 2 18:40:03 2008

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