Lactoferrin
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
| - | LTF is a bilobal protein with the <scene name='45/455488/Cv/ | + | LTF is a bilobal protein with the <scene name='45/455488/Cv/7'>N-terminal half and the C-terminal half called N-lobe and C-lobe</scene>. LTF binds with high affinity Fe+3 ion and an anion in both its N-lobe and its C-lobe<ref>PMID:8703903</ref>. The binding site is between the 2 domains of each lobe. |
| - | <scene name='45/455488/Cv/ | + | <scene name='45/455488/Cv/8'>N-lobe binding site</scene>. |
| - | The <scene name='45/455488/Cv/ | + | The <scene name='45/455488/Cv/9'>anion binds the Fe+3 in a 1,2 bidendate fashion</scene>. |
| - | <scene name='45/455488/Cv/ | + | <scene name='45/455488/Cv/10'>C-lobe binding site</scene>. |
| - | The <scene name='45/455488/Cv/ | + | The <scene name='45/455488/Cv/11'>anion binds the Fe+3 in a 1,2 bidendate fashion</scene>. |
</StructureSection> | </StructureSection> | ||
Revision as of 10:41, 4 July 2019
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3D Structures of lactoferrin
Updated on 04-July-2019
References
- ↑ Actor JK, Hwang SA, Kruzel ML. Lactoferrin as a natural immune modulator. Curr Pharm Des. 2009;15(17):1956-73. PMID:19519436
- ↑ Farnaud S, Evans RW. Lactoferrin--a multifunctional protein with antimicrobial properties. Mol Immunol. 2003 Nov;40(7):395-405. PMID:14568385
- ↑ Kayazawa M, Saitoh O, Kojima K, Nakagawa K, Tanaka S, Tabata K, Matsuse R, Uchida K, Hoshimoto M, Hirata I, Katsu K. Lactoferrin in whole gut lavage fluid as a marker for disease activity in inflammatory bowel disease: comparison with other neutrophil-derived proteins. Am J Gastroenterol. 2002 Feb;97(2):360-9. PMID:11866274 doi:http://dx.doi.org/10.1111/j.1572-0241.2002.05470.x
- ↑ Baker HM, Anderson BF, Brodie AM, Shongwe MS, Smith CA, Baker EN. Anion binding by transferrins: importance of second-shell effects revealed by the crystal structure of oxalate-substituted diferric lactoferrin. Biochemistry. 1996 Jul 16;35(28):9007-13. PMID:8703903 doi:10.1021/bi960288y
