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Mannosidase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='4jie' size=' | + | <StructureSection load='4jie' size='350' side='right' caption='Rice β-mannosidase complex with β-mannose, glycerol and HEPES (PDB entry [[4jie]])' scene='45/458458/Cv/1'> |
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
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**[[1fo2]] - hαMAN I + deoxymannojirimycin<br /> | **[[1fo2]] - hαMAN I + deoxymannojirimycin<br /> | ||
**[[1fo3]] - hαMAN I+ kifunensine<br /> | **[[1fo3]] - hαMAN I+ kifunensine<br /> | ||
| - | **[[1dl2]] - | + | **[[5jm0]] - yαMAN I – yeast<br /> |
| + | **[[1dl2]] - yαMAN I catalytic domain + mannose - yeast<br /> | ||
**[[2ri8]] - PcαMAN I + glycerol – ''Penicillium citrinum''<br /> | **[[2ri8]] - PcαMAN I + glycerol – ''Penicillium citrinum''<br /> | ||
**[[1kre]], [[1kkt]] - PcαMAN I + mannose<br /> | **[[1kre]], [[1kkt]] - PcαMAN I + mannose<br /> | ||
| Line 81: | Line 82: | ||
**[[4jho]] - rβMAN – rice<br /> | **[[4jho]] - rβMAN – rice<br /> | ||
**[[4jie]] - rβMAN + β-mannose<br /> | **[[4jie]] - rβMAN + β-mannose<br /> | ||
| + | **[[4cvu]], [[4uoj]] – βMAN - ''Trichoderma harzianum''<br /> | ||
| + | **[[5n6u]] - βMAN + β-mannose – ''Dictyoglomus thermophilum''<br /> | ||
*Mannan endo-1,4-β-MAN | *Mannan endo-1,4-β-MAN | ||
| Line 87: | Line 90: | ||
**[[1j9y]], [[1r7o]] - PcβMAN<br /> | **[[1j9y]], [[1r7o]] - PcβMAN<br /> | ||
**[[2c0h]] - βMAN (mutant) – blue mussel<br /> | **[[2c0h]] - βMAN (mutant) – blue mussel<br /> | ||
| - | **[[2whk]] - βMAN – ''Bacillus subtilis''<br /> | + | **[[2whk]], [[4yn5]] - βMAN – ''Bacillus subtilis''<br /> |
**[[1rh9]] – βMAN – ''Solanum lycopersicum''<br /> | **[[1rh9]] – βMAN – ''Solanum lycopersicum''<br /> | ||
**[[3pz9]], [[3pzg]] – TpβMAN – ''Thermotoga petrophila''<br /> | **[[3pz9]], [[3pzg]] – TpβMAN – ''Thermotoga petrophila''<br /> | ||
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**[[3pzm]], [[3pzn]] – TpβMAN + glycerol<br /> | **[[3pzm]], [[3pzn]] – TpβMAN + glycerol<br /> | ||
**[[3pzo]], [[3pzq]] – TpβMAN + maltose | **[[3pzo]], [[3pzq]] – TpβMAN + maltose | ||
| + | |||
| + | *Exo-β-1,4-MAN | ||
| + | |||
| + | **[[4lyp]] - RmβMAN – Rhizomucor miehei<br /> | ||
| + | **[[4lyq]], [[4lyr]] - RmβMAN (mutant)<br /> | ||
| + | **[[4nrr]] - RmβMAN (mutant) + mannosyl-fructose<br /> | ||
| + | **[[4nrs]] - RmβMAN (mutant) + mannobiose<br /> | ||
| + | |||
| + | *Exo-α-1,6-MAN | ||
| + | |||
| + | **[[5m7i]] - CpαMAN (mutant) + mannobiose – Clostridium perfringenes<br /> | ||
| + | **[[5m7i]] - CpαMAN (mutant) + mannotriose <br /> | ||
| + | |||
| + | *β-MAN/β-glucosidase | ||
| + | |||
| + | **[[4re2, [[4re3]], [[4re4]] - rβMAN/βGLU – rice<br /> | ||
}} | }} | ||
Revision as of 07:54, 10 July 2017
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3D structures of mannosidase
Updated on 10-July-2017 {{#tree:id=OrganizedByTopic|openlevels=0|
- α-MAN
- α-MAN class I
- 1fmi - hαMAN I - human
- 1fo2 - hαMAN I + deoxymannojirimycin
- 1fo3 - hαMAN I+ kifunensine
- 5jm0 - yαMAN I – yeast
- 1dl2 - yαMAN I catalytic domain + mannose - yeast
- 2ri8 - PcαMAN I + glycerol – Penicillium citrinum
- 1kre, 1kkt - PcαMAN I + mannose
- 2ri9 - PcαMAN I + substrate analog
- 1krf - PcαMAN I + kifunensine + mannose
- 1x9d - hαMAN I residues 243-699 + polysaccharide analog
- 1nxc - αMAN I + mannose – mouse
- 1g6i - αMAN I + deoxymannojirimycin
- 1fmi - hαMAN I - human
- α-MAN class II
- 2wyh - SpαMAN II – Streptococcus pyrogenes
- 3bub, 1hty - DmαMAN II catalytic domain – Drosophila melanogaster
- 3bud - DmαMAN II catalytic domain (mutant)
- 3bui - DmαMAN II catalytic domain (mutant) + Tris
- 3bup, 3buq, 3czs - DmαMAN II catalytic domain (mutant) + mannose
- 3bvt, 3bvu, 3bvv, 3bvw, 3bvx - DmαMAN II catalytic domain (mutant) + mannopyranoside
- 1r33, 1r34 - DmαMAN II catalytic domain + mannopyranoside
- 3ddf, 3ddg, 2f18, 2f1a, 2f1b - DmαMAN II catalytic domain + pyrrolidin
- 2alw - DmαMAN II catalytic domain + noeuromycin
- 3cv5 - DmαMAN II catalytic domain + polysaccharide
- 3czn - DmαMAN II catalytic domain (mutant) + polysaccharide
- 2wyi - SpαMAN II + swainsonine
- 3blb, 1hww - DmαMAN II + swainsonine
- 3ejp, 3ejq, 3ejr, 3ejs, 3ejt, 3eju, 2ow6, 2ow7 - DmαMAN II catalytic domain + swainsonine analog
- 3dx0, 3dx2, 2f7o - DmαMAN II catalytic domain + mannostatine
- 3dx1, 3dx3, 3dx4, 2f7p - DmαMAN II catalytic domain + mannostatine analog
- 3d4y, 3d4z - DmαMAN II catalytic domain + imidazole derivative
- 3d50, 3d51, 3d52 - DmαMAN II catalytic domain + inhibitor
- 2fyv, 2f7q, 2f7r - DmαMAN II catalytic domain + amino-salacinol carboxylate analog
- 1tqv, 1tqw, 1tqs, 1tqt, 1tqu - DmαMAN II catalytic domain (mutant) + seleno-salacinol
- 1ps3 - DmαMAN II catalytic domain + kifunensine
- 1qwn - DmαMAN II catalytic domain + intermediate
- 1hxk - DmαMAN II catalytic domain + deoxymannojirimycin
- 1qwu - DmαMAN II catalytic domain (mutant) + guloside
- 1qx1 - DmαMAN II catalytic domain (mutant) + mannosyl
- 2wyh - SpαMAN II – Streptococcus pyrogenes
- α-1,2-MAN
- β-MAN
- 2je8 - BtβMAN residues 26-864
- 2wbk - BtβMAN residues 26-864 + mannopyranoside
- 2vqt, 2vr4, 2vjx, 2vl4, 2vmf, 2vo5, 2vot, 2vqu - BtβMAN residues 26-864 + piperidine derivative
- 1oh4, 1of4 - TmβMAN catalytic domain + mannose – Thermotoga maritima
- 1of3 - TmβMAN catalytic domain
- 1uz4 - CmβMAN + inhibitor – Cellvibrio mixtus
- 1uuq - CmβMAN
- 2whk - βMAN – Bacillus subtilis
- 4jho - rβMAN – rice
- 4jie - rβMAN + β-mannose
- 4cvu, 4uoj – βMAN - Trichoderma harzianum
- 5n6u - βMAN + β-mannose – Dictyoglomus thermophilum
- 2je8 - BtβMAN residues 26-864
- Mannan endo-1,4-β-MAN
- 1gvy, 1odz, 1gw1, 2whm - PcβMAN (mutant) + mannose derivative – Pseudomonas cellulosa
- 1j9y, 1r7o - PcβMAN
- 2c0h - βMAN (mutant) – blue mussel
- 2whk, 4yn5 - βMAN – Bacillus subtilis
- 1rh9 – βMAN – Solanum lycopersicum
- 3pz9, 3pzg – TpβMAN – Thermotoga petrophila
- 3pzi – TpβMAN + glucose
- 3pzm, 3pzn – TpβMAN + glycerol
- 3pzo, 3pzq – TpβMAN + maltose
- 1gvy, 1odz, 1gw1, 2whm - PcβMAN (mutant) + mannose derivative – Pseudomonas cellulosa
- Exo-β-1,4-MAN
- Exo-α-1,6-MAN
- β-MAN/β-glucosidase
}}
References
- ↑ Heikinheimo P, Helland R, Leiros HK, Leiros I, Karlsen S, Evjen G, Ravelli R, Schoehn G, Ruigrok R, Tollersrud OK, McSweeney S, Hough E. The structure of bovine lysosomal alpha-mannosidase suggests a novel mechanism for low-pH activation. J Mol Biol. 2003 Mar 28;327(3):631-44. PMID:12634058
- ↑ Ademark P, Lundqvist J, Hagglund P, Tenkanen M, Torto N, Tjerneld F, Stalbrand H. Hydrolytic properties of a beta-mannosidase purified from Aspergillus niger. J Biotechnol. 1999 Oct 8;75(2-3):281-9. PMID:10553664
- ↑ Berg T, Riise HM, Hansen GM, Malm D, Tranebjaerg L, Tollersrud OK, Nilssen O. Spectrum of mutations in alpha-mannosidosis. Am J Hum Genet. 1999 Jan;64(1):77-88. PMID:9915946 doi:http://dx.doi.org/S0002-9297(07)61660-7
- ↑ Uchino Y, Fukushige T, Yotsumoto S, Hashiguchi T, Taguchi H, Suzuki N, Konohana I, Kanzaki T. Morphological and biochemical studies of human beta-mannosidosis: identification of a novel beta-mannosidase gene mutation. Br J Dermatol. 2003 Jul;149(1):23-9. PMID:12890191
- ↑ Tankrathok A, Iglesias-Fernandez J, Luang S, Robinson RC, Kimura A, Rovira C, Hrmova M, Ketudat Cairns JR. Structural analysis and insights into the glycon specificity of the rice GH1 Os7BGlu26 beta-D-mannosidase. Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2124-35. doi:, 10.1107/S0907444913020568. Epub 2013 Sep 20. PMID:24100330 doi:http://dx.doi.org/10.1107/S0907444913020568
