1hc9
From Proteopedia
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'''A-BUNGAROTOXIN COMPLEXED WITH HIGH AFFINITY PEPTIDE''' | '''A-BUNGAROTOXIN COMPLEXED WITH HIGH AFFINITY PEPTIDE''' | ||
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[[Category: Sussman, J L.]] | [[Category: Sussman, J L.]] | ||
[[Category: 3-finger]] | [[Category: 3-finger]] | ||
| - | [[Category: | + | [[Category: Acetylcholine receptor mimitope]] |
| - | [[Category: | + | [[Category: Alpha-bungarotoxin]] |
| - | [[Category: | + | [[Category: Protein-peptide complex]] |
| - | [[Category: | + | [[Category: Toxin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:41:28 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 15:41, 2 May 2008
A-BUNGAROTOXIN COMPLEXED WITH HIGH AFFINITY PEPTIDE
Overview
We have determined the crystal structure at 1.8 A resolution of a complex of alpha-bungarotoxin with a high affinity 13-residue peptide that is homologous to the binding region of the alpha subunit of acetylcholine receptor. The peptide fits snugly to the toxin and adopts a beta hairpin conformation. The structures of the bound peptide and the homologous loop of acetylcholine binding protein, a soluble analog of the extracellular domain of acetylcholine receptor, are remarkably similar. Their superposition indicates that the toxin wraps around the receptor binding site loop, and in addition, binds tightly at the interface of two of the receptor subunits where it inserts a finger into the ligand binding site, thus blocking access to the acetylcholine binding site and explaining its strong antagonistic activity.
About this Structure
1HC9 is a Protein complex structure of sequences from Bungarus multicinctus. Full crystallographic information is available from OCA.
Reference
The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide., Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S, Neuron. 2001 Oct 25;32(2):265-75. PMID:11683996 Page seeded by OCA on Fri May 2 18:41:28 2008
