1hcq

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[[Image:1hcq.gif|left|200px]]
[[Image:1hcq.gif|left|200px]]
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{{Structure
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|PDB= 1hcq |SIZE=350|CAPTION= <scene name='initialview01'>1hcq</scene>, resolution 2.400&Aring;
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The line below this paragraph, containing "STRUCTURE_1hcq", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1hcq| PDB=1hcq | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hcq OCA], [http://www.ebi.ac.uk/pdbsum/1hcq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hcq RCSB]</span>
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'''THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS'''
'''THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS'''
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[[Category: Rhodes, D.]]
[[Category: Rhodes, D.]]
[[Category: Schwabe, J W.R.]]
[[Category: Schwabe, J W.R.]]
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[[Category: complexed with drug]]
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[[Category: Complexed with drug]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:42:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:02:23 2008''
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Revision as of 15:42, 2 May 2008

Image:1hcq.gif

Template:STRUCTURE 1hcq

THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS


Overview

The nuclear hormone receptors are a superfamily of ligand-activated DNA-binding transcription factors. We have determined the crystal structure (at 2.4 A) of the fully specific complex between the DNA-binding domain from the estrogen receptor and DNA. The protein binds as a symmetrical dimer to its palindromic binding site consisting of two 6 bp consensus half sites with three intervening base pairs. This structure reveals how the protein recognizes its own half site sequence rather than that of the related glucocorticoid receptor, which differs by only two base pairs. Since all nuclear hormone receptors recognize one or the other of these two consensus half site sequences, this recognition mechanism applies generally to the whole receptor family.

About this Structure

1HCQ is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1HCQ with [Estrogen Receptor]. Full crystallographic information is available from OCA.

Reference

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements., Schwabe JW, Chapman L, Finch JT, Rhodes D, Cell. 1993 Nov 5;75(3):567-78. PMID:8221895 Page seeded by OCA on Fri May 2 18:42:21 2008

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OCA

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