1hcx

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[[Image:1hcx.gif|left|200px]]
[[Image:1hcx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1hcx |SIZE=350|CAPTION= <scene name='initialview01'>1hcx</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1hcx", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=1:Tpt+Binding+Site+For+Chain+A'>1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CHT:CHOLINE+ION'>CHT</scene>, <scene name='pdbligand=DDQ:DECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DDQ</scene>, <scene name='pdbligand=TPT:2,2&#39;&#58;6&#39;,2&#39;&#39;-TERPYRIDINE+PLATINUM(II)'>TPT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylmuramoyl-L-alanine_amidase N-acetylmuramoyl-L-alanine amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.28 3.5.1.28] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= LYTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])
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-->
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|DOMAIN=
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{{STRUCTURE_1hcx| PDB=1hcx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hcx OCA], [http://www.ebi.ac.uk/pdbsum/1hcx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hcx RCSB]</span>
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}}
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'''CHOLINE BINDING DOMAIN OF THE MAJOR AUTOLYSIN (C-LYTA) FROM STREPTOCOCCUS PNEUMONIAE'''
'''CHOLINE BINDING DOMAIN OF THE MAJOR AUTOLYSIN (C-LYTA) FROM STREPTOCOCCUS PNEUMONIAE'''
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[[Category: Lopez, R.]]
[[Category: Lopez, R.]]
[[Category: Romero, A.]]
[[Category: Romero, A.]]
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[[Category: cell wall attachment]]
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[[Category: Cell wall attachment]]
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[[Category: choline-binding domain]]
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[[Category: Choline-binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:42:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:02:31 2008''
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Revision as of 15:42, 2 May 2008

Image:1hcx.gif

Template:STRUCTURE 1hcx

CHOLINE BINDING DOMAIN OF THE MAJOR AUTOLYSIN (C-LYTA) FROM STREPTOCOCCUS PNEUMONIAE


Overview

Choline binding proteins are virulence determinants present in several Gram-positive bacteria. Because anchorage of these proteins to the cell wall through their choline binding domain is essential for bacterial virulence, their release from the cell surface is considered a powerful target for a weapon against these pathogens. The first crystal structure of a choline binding domain, from the toxin-releasing enzyme pneumococcal major autolysin (LytA), reveals a novel solenoid fold consisting exclusively of beta-hairpins that stack to form a left-handed superhelix. This unique structure is maintained by choline molecules at the hydrophobic interface of consecutive hairpins and may be present in other choline binding proteins that share high homology to the repeated motif of the domain.

About this Structure

1HCX is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

A novel solenoid fold in the cell wall anchoring domain of the pneumococcal virulence factor LytA., Fernandez-Tornero C, Lopez R, Garcia E, Gimenez-Gallego G, Romero A, Nat Struct Biol. 2001 Dec;8(12):1020-4. PMID:11694890 Page seeded by OCA on Fri May 2 18:42:46 2008

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OCA

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