1he2

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[[Image:1he2.jpg|left|200px]]
[[Image:1he2.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1he2 |SIZE=350|CAPTION= <scene name='initialview01'>1he2</scene>, resolution 1.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1he2", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Nap+Binding+Site+For+Chain+A'>AC1</scene> and <scene name='pdbsite=AC2:Bla+Binding+Site+For+Chain+A'>AC2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BLA:BILIVERDINE+IX+ALPHA'>BLA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1he2| PDB=1he2 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1he2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he2 OCA], [http://www.ebi.ac.uk/pdbsum/1he2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1he2 RCSB]</span>
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}}
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'''HUMAN BILIVERDIN IX BETA REDUCTASE: NADP/BILIVERDIN IX ALPHA TERNARY COMPLEX'''
'''HUMAN BILIVERDIN IX BETA REDUCTASE: NADP/BILIVERDIN IX ALPHA TERNARY COMPLEX'''
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[[Category: Pereira, P J.B.]]
[[Category: Pereira, P J.B.]]
[[Category: Perez-Luque, R.]]
[[Category: Perez-Luque, R.]]
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[[Category: alpha/beta dinucleotide binding fold]]
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[[Category: Alpha/beta dinucleotide binding fold]]
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[[Category: biliverdin-ix beta reductase]]
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[[Category: Biliverdin-ix beta reductase]]
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[[Category: diaphorase]]
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[[Category: Diaphorase]]
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[[Category: flavin reductase]]
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[[Category: Flavin reductase]]
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[[Category: foetal metabolism]]
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[[Category: Foetal metabolism]]
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[[Category: green haem binding protein]]
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[[Category: Green haem binding protein]]
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[[Category: haem degradation]]
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[[Category: Haem degradation]]
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[[Category: methaemoglobin reductase]]
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[[Category: Methaemoglobin reductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:45:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:03:13 2008''
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Revision as of 15:45, 2 May 2008

Image:1he2.jpg

Template:STRUCTURE 1he2

HUMAN BILIVERDIN IX BETA REDUCTASE: NADP/BILIVERDIN IX ALPHA TERNARY COMPLEX


Overview

Biliverdin IXbeta reductase (BVR-B) catalyzes the pyridine nucleotide-dependent production of bilirubin-IXbeta, the major heme catabolite during early fetal development. BVR-B displays a preference for biliverdin isomers without propionates straddling the C10 position, in contrast to biliverdin IXalpha reductase (BVR-A), the major form of BVR in adult human liver. In addition to its tetrapyrrole clearance role in the fetus, BVR-B has flavin and ferric reductase activities in the adult. We have solved the structure of human BVR-B in complex with NADP+ at 1.15 A resolution. Human BVR-B is a monomer displaying an alpha/beta dinucleotide binding fold. The structures of ternary complexes with mesobiliverdin IValpha, biliverdin IXalpha, FMN and lumichrome show that human BVR-B has a single substrate binding site, to which substrates and inhibitors bind primarily through hydrophobic interactions, explaining its broad specificity. The reducible atom of both biliverdin and flavin substrates lies above the reactive C4 of the cofactor, an appropriate position for direct hydride transfer. BVR-B discriminates against the biliverdin IXalpha isomer through steric hindrance at the bilatriene side chain binding pockets. The structure also explains the enzyme's preference for NADP(H) and its B-face stereospecificity.

About this Structure

1HE2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme., Pereira PJ, Macedo-Ribeiro S, Parraga A, Perez-Luque R, Cunningham O, Darcy K, Mantle TJ, Coll M, Nat Struct Biol. 2001 Mar;8(3):215-20. PMID:11224564 Page seeded by OCA on Fri May 2 18:45:02 2008

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