NAD(P) transhydrogenase
From Proteopedia
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<StructureSection load='1u28' size='350' side='right' caption='Structure of PTH domains I (grey and green) and III (pink) complex with NAD and NADP (PDB entry [[1u28]])' scene=''> | <StructureSection load='1u28' size='350' side='right' caption='Structure of PTH domains I (grey and green) and III (pink) complex with NAD and NADP (PDB entry [[1u28]])' scene=''> | ||
| - | '''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor. PTH is composed of 3 domains | + | '''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor. |
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| + | == Structural highlights == | ||
| + | PTH is composed of 3 domains:<br /> | ||
* Domain I binds NAD(+)/NADH.<br /> | * Domain I binds NAD(+)/NADH.<br /> | ||
* Domain II is a membrane-spanning domain.<br /> | * Domain II is a membrane-spanning domain.<br /> | ||
Revision as of 11:00, 4 May 2016
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3D structures of NAD(P) transhydrogenase
Updated on 04-May-2016
References
- ↑ Jackson JB. Proton translocation by transhydrogenase. FEBS Lett. 2003 Jun 12;545(1):18-24. PMID:12788487
