This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Neuropilin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
{{STRUCTURE_2qqm| PDB=2qqm | SIZE=400| SCENE= |right|CAPTION=Human neuropilin-1 glycosylated complex with ethylene glycol and Ca+2 ion, [[2qqm]] }}
{{STRUCTURE_2qqm| PDB=2qqm | SIZE=400| SCENE= |right|CAPTION=Human neuropilin-1 glycosylated complex with ethylene glycol and Ca+2 ion, [[2qqm]] }}
-
+
== Function ==
'''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins<ref>PMID:12613542</ref>. There are 2 classes of NRP – NRP-1 and NRP-2.<br />
'''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins<ref>PMID:12613542</ref>. There are 2 classes of NRP – NRP-1 and NRP-2.<br />
* '''NRP-1''' has high affinity for semaphorin-3A.<br />
* '''NRP-1''' has high affinity for semaphorin-3A.<br />
* '''NRP-2''' has high affinity for semaphorin-3F.
* '''NRP-2''' has high affinity for semaphorin-3F.
 +
 +
== Relevance ==
 +
NRP are highly expressed in human neoplasms<ref>PMID:18363553</ref>.
== 3D Structures of Neuropilin ==
== 3D Structures of Neuropilin ==

Revision as of 10:06, 10 May 2016

Template:STRUCTURE 2qqm

Contents

Function

Neuropilin (NRP) are neuronal receptors. NRP are co-receptors for semaphorins[1]. There are 2 classes of NRP – NRP-1 and NRP-2.

  • NRP-1 has high affinity for semaphorin-3A.
  • NRP-2 has high affinity for semaphorin-3F.

Relevance

NRP are highly expressed in human neoplasms[2].

3D Structures of Neuropilin

Updated on 10-May-2016

References

  1. ↑ Romeo PH, Lemarchandel V, Tordjman R. Neuropilin-1 in the immune system. Adv Exp Med Biol. 2002;515:49-54. PMID:12613542
  2. ↑ Pellet-Many C, Frankel P, Jia H, Zachary I. Neuropilins: structure, function and role in disease. Biochem J. 2008 Apr 15;411(2):211-26. doi: 10.1042/BJ20071639. PMID:18363553 doi:http://dx.doi.org/10.1042/BJ20071639

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Neuropilin"
Personal tools