1hl3

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[[Image:1hl3.jpg|left|200px]]
[[Image:1hl3.jpg|left|200px]]
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{{Structure
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|PDB= 1hl3 |SIZE=350|CAPTION= <scene name='initialview01'>1hl3</scene>, resolution 3.1&Aring;
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{{STRUCTURE_1hl3| PDB=1hl3 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hl3 OCA], [http://www.ebi.ac.uk/pdbsum/1hl3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hl3 RCSB]</span>
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'''CTBP/BARS IN TERNARY COMPLEX WITH NAD(H) AND PIDLSKK PEPTIDE'''
'''CTBP/BARS IN TERNARY COMPLEX WITH NAD(H) AND PIDLSKK PEPTIDE'''
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[[Category: Pesce, A.]]
[[Category: Pesce, A.]]
[[Category: Spano , S.]]
[[Category: Spano , S.]]
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[[Category: acyl-coa]]
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[[Category: Acyl-coa]]
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[[Category: acyltransferase]]
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[[Category: Acyltransferase]]
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[[Category: brefeldin some]]
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[[Category: Brefeldin some]]
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[[Category: golgi membrane]]
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[[Category: Golgi membrane]]
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[[Category: nad]]
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[[Category: Nad]]
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[[Category: transcription co-repression]]
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[[Category: Transcription co-repression]]
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Revision as of 15:58, 2 May 2008

Image:1hl3.jpg

Template:STRUCTURE 1hl3

CTBP/BARS IN TERNARY COMPLEX WITH NAD(H) AND PIDLSKK PEPTIDE


Overview

C-terminal-binding protein/brefeldin A-ADP ribosylated substrate (CtBP/BARS) plays key roles in development and oncogenesis as a transcription co-repressor, and in intracellular traffic as a promoter of Golgi membrane fission. Co-repressor activity is regulated by NAD(H) binding to CtBP/BARS, while membrane fission is associated with its acyl-CoA-dependent acyltransferase activity. Here, we report the crystal structures of rat CtBP/BARS in a binary complex with NAD(H), and in a ternary complex with a PIDLSKK peptide mimicking the consensus motif (PXDLS) recognized in CtBP/BARS cellular partners. The structural data show CtBP/BARS in a NAD(H)-bound dimeric form; the peptide binding maps the recognition site for DNA-binding proteins and histone deacetylases to an N-terminal region of the protein. The crystal structure together with the site-directed mutagenesis data and binding experiments suggest a rationale for the molecular mechanisms underlying the two fundamental co-existing, but diverse, activities supported by CtBP/BARS in the nucleus and in Golgi membranes.

About this Structure

1HL3 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission., Nardini M, Spano S, Cericola C, Pesce A, Massaro A, Millo E, Luini A, Corda D, Bolognesi M, EMBO J. 2003 Jun 16;22(12):3122-30. PMID:12805226 Page seeded by OCA on Fri May 2 18:58:12 2008

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