1hmj

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[[Image:1hmj.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hmj OCA], [http://www.ebi.ac.uk/pdbsum/1hmj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hmj RCSB]</span>
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'''SOLUTION STRUCTURE OF RNA POLYMERASE SUBUNIT H'''
'''SOLUTION STRUCTURE OF RNA POLYMERASE SUBUNIT H'''
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[[Category: Thiru, A.]]
[[Category: Thiru, A.]]
[[Category: Weinzierl, R.]]
[[Category: Weinzierl, R.]]
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[[Category: archaea]]
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[[Category: Archaea]]
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[[Category: rna polymerase]]
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[[Category: Rna polymerase]]
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[[Category: rpb5]]
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[[Category: Rpb5]]
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[[Category: subunit h]]
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[[Category: Subunit h]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:01:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:07:41 2008''
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Revision as of 16:01, 2 May 2008

Image:1hmj.gif

Template:STRUCTURE 1hmj

SOLUTION STRUCTURE OF RNA POLYMERASE SUBUNIT H


Overview

The archaeal H and eukaryotic RPB5 RNA polymerase subunits are highly homologous and are likely to play a fundamental role in transcription that extends from archaea to humans. We report the structure of subunit H, in solution, from the archaeon Methanococcus jannaschii using multidimensional nuclear magnetic resonance. The structure reveals a novel fold containing a four-stranded mixed beta sheet that is flanked on one side by three short helices. The dominant feature is beta-ribbon motif, which presents a hydrophobic, basic surface, and defines a general RNA polymerase architectural scaffold.

About this Structure

1HMJ is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

RNA polymerase subunit H features a beta-ribbon motif within a novel fold that is present in archaea and eukaryotes., Thiru A, Hodach M, Eloranta JJ, Kostourou V, Weinzierl RO, Matthews S, J Mol Biol. 1999 Apr 9;287(4):753-60. PMID:10191143 Page seeded by OCA on Fri May 2 19:01:00 2008

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