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| | ==Ubiquitin-like domain of the mycobacterium tuberculosis type VII secretion system protein ECCD1== | | ==Ubiquitin-like domain of the mycobacterium tuberculosis type VII secretion system protein ECCD1== |
| - | <StructureSection load='4kv2' size='340' side='right' caption='[[4kv2]], [[Resolution|resolution]] 1.88Å' scene=''> | + | <StructureSection load='4kv2' size='340' side='right'caption='[[4kv2]], [[Resolution|resolution]] 1.88Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4kv2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KV2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4kv2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KV2 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kv3|4kv3]]</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kv2 OCA], [https://pdbe.org/4kv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kv2 RCSB], [https://www.ebi.ac.uk/pdbsum/4kv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kv2 ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv3877, RVBD_3877 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kv2 OCA], [http://pdbe.org/4kv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kv2 RCSB], [http://www.ebi.ac.uk/pdbsum/4kv2 PDBsum]</span></td></tr> | + | |
| | </table> | | </table> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Myctu]] | + | [[Category: Large Structures]] |
| - | [[Category: Evans, T J]] | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | [[Category: Korotkov, K V]] | + | [[Category: Evans TJ]] |
| - | [[Category: Esx]] | + | [[Category: Korotkov KV]] |
| - | [[Category: Esx-1]]
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| - | [[Category: Membrane protein]]
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| - | [[Category: Pf08817]]
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| - | [[Category: Protein secretion]]
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| - | [[Category: Protein transport]]
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| - | [[Category: Snm4]]
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| - | [[Category: Ubiquitin]]
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| - | [[Category: Yukd]]
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| Structural highlights
Publication Abstract from PubMed
BACKGROUND: The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its important role in disease very little is known about the molecular architecture of the ESX-1 secretion system. RESULTS: This study characterizes the structures of the soluble domains of two conserved core ESX-1 components - EccB1 and EccD1. The periplasmic domain of EccB1 consists of 4 repeat domains and a central domain, which together form a quasi 2-fold symmetrical structure. The repeat domains of EccB1 are structurally similar to a known peptidoglycan binding protein suggesting a role in anchoring the ESX-1 system within the periplasmic space. The cytoplasmic domain of EccD1has a ubiquitin-like fold and forms a dimer with a negatively charged groove. CONCLUSIONS: These structures represent a major step towards resolving the molecular architecture of the entire ESX-1 assembly and may contribute to ESX-1 targeted tuberculosis intervention strategies.
Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.,Wagner JM, Chan S, Evans TJ, Kahng S, Kim J, Arbing MA, Eisenberg D, Korotkov KV BMC Struct Biol. 2016 Feb 27;16(1):5. doi: 10.1186/s12900-016-0056-6. PMID:26922638[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Wagner JM, Chan S, Evans TJ, Kahng S, Kim J, Arbing MA, Eisenberg D, Korotkov KV. Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system. BMC Struct Biol. 2016 Feb 27;16(1):5. doi: 10.1186/s12900-016-0056-6. PMID:26922638 doi:http://dx.doi.org/10.1186/s12900-016-0056-6
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