2rvp

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m (Protected "2rvp" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 2rvp is ON HOLD until Mar 21 2018
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==Solution structure of DNA Containing Metallo-Base-Pair==
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<StructureSection load='2rvp' size='340' side='right' caption='[[2rvp]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2rvp]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RVP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RVP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG:SILVER+ION'>AG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rvp OCA], [http://pdbe.org/2rvp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rvp RCSB], [http://www.ebi.ac.uk/pdbsum/2rvp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rvp ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of an Ag(I) -mediated cytosine-cytosine base pair, C-Ag(I) -C, was determined with NMR spectroscopy in solution. The observation of 1-bond (15) N-(109) Ag J-coupling ((1) J((15) N,(109) Ag): 83 and 84 Hz) recorded within the C-Ag(I) -C base pair evidenced the N3-Ag(I) -N3 linkage in C-Ag(I) -C. The triplet resonances of the N4 atoms in C-Ag(I) -C demonstrated that each exocyclic N4 atom exists as an amino group (-NH2 ), and any isomerization and/or N4-Ag(I) bonding can be excluded. The 3D structure of Ag(I) -DNA complex determined with NOEs was classified as a B-form conformation with a notable propeller twist of C-Ag(I) -C (-18.3+/-3.0 degrees ). The (109) Ag NMR chemical shift of C-Ag(I) -C was recorded for cytidine/Ag(I) complex (delta((109) Ag): 442 ppm) to completed full NMR characterization of the metal linkage. The structural interpretation of NMR data with quantum mechanical calculations corroborated the structure of the C-Ag(I) -C base pair.
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Authors: Dairaku, T., Furuita, K., Sato, H., Sebera, J., Nakashima, K., Kondo, J., Yamanaka, D., Kondo, Y., Okamoto, I., Ono, A., Sychrovsky, V., Kojima, C., Tanaka, Y.
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Structure Determination of an Ag(I) -Mediated Cytosine-Cytosine Base Pair within DNA Duplex in Solution with (1) H/(15) N/(109) Ag NMR Spectroscopy.,Dairaku T, Furuita K, Sato H, Sebera J, Nakashima K, Kondo J, Yamanaka D, Kondo Y, Okamoto I, Ono A, Sychrovsky V, Kojima C, Tanaka Y Chemistry. 2016 Sep 5;22(37):13028-31. doi: 10.1002/chem.201603048. Epub 2016 Aug, 9. PMID:27505707<ref>PMID:27505707</ref>
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Description: Solution structure of DNA Containing Metallo-Base-Pair
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Yamanaka, D]]
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<div class="pdbe-citations 2rvp" style="background-color:#fffaf0;"></div>
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[[Category: Kondo, J]]
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== References ==
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[[Category: Okamoto, I]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Dairaku, T]]
[[Category: Furuita, K]]
[[Category: Furuita, K]]
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[[Category: Sebera, J]]
 
[[Category: Kojima, C]]
[[Category: Kojima, C]]
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[[Category: Kondo, J]]
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[[Category: Kondo, Y]]
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[[Category: Nakashima, K]]
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[[Category: Okamoto, I]]
[[Category: Ono, A]]
[[Category: Ono, A]]
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[[Category: Dairaku, T]]
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[[Category: Sato, H]]
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[[Category: Sebera, J]]
[[Category: Sychrovsky, V]]
[[Category: Sychrovsky, V]]
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[[Category: Nakashima, K]]
 
[[Category: Tanaka, Y]]
[[Category: Tanaka, Y]]
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[[Category: Kondo, Y]]
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[[Category: Yamanaka, D]]
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[[Category: Sato, H]]
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[[Category: Dna]]
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[[Category: Metallo-base-pair]]
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[[Category: Metallo-dna]]

Revision as of 13:52, 10 September 2016

Solution structure of DNA Containing Metallo-Base-Pair

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