1ho3

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[[Image:1ho3.gif|left|200px]]
[[Image:1ho3.gif|left|200px]]
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{{Structure
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|PDB= 1ho3 |SIZE=350|CAPTION= <scene name='initialview01'>1ho3</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1ho3", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Asparaginase Asparaginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.1 3.5.1.1] </span>
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{{STRUCTURE_1ho3| PDB=1ho3 | SCENE= }}
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|RELATEDENTRY=[[3eca|3ECA]], [[4eca|4ECA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ho3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ho3 OCA], [http://www.ebi.ac.uk/pdbsum/1ho3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ho3 RCSB]</span>
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'''CRYSTAL STRUCTURE ANALYSIS OF E. COLI L-ASPARAGINASE II (Y25F MUTANT)'''
'''CRYSTAL STRUCTURE ANALYSIS OF E. COLI L-ASPARAGINASE II (Y25F MUTANT)'''
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[[Category: Palm, J G.]]
[[Category: Palm, J G.]]
[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
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[[Category: asparaginase]]
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[[Category: Asparaginase]]
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[[Category: leukemia]]
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[[Category: Leukemia]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:03:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:08:14 2008''
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Revision as of 16:03, 2 May 2008

Image:1ho3.gif

Template:STRUCTURE 1ho3

CRYSTAL STRUCTURE ANALYSIS OF E. COLI L-ASPARAGINASE II (Y25F MUTANT)


Overview

Quasi-enantiomorphic crystals of the Y25F mutant of Escherichia coli L-asparaginase and of the native Erwinia chrysanthemi L-asparaginase were obtained in the hexagonal space groups P6(5)22 and P6(1)22, respectively. The structures of these highly homologous enzymes were solved by molecular replacement and were refined with data extending to 2.2-2.5 A. These structures were compared with each other, as well as with other L-asparaginase structures previously observed with different crystal packing. It is concluded that the observed phenomenon, which is rare, was most likely to have arisen by chance.

About this Structure

1HO3 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structures of two highly homologous bacterial L-asparaginases: a case of enantiomorphic space groups., Jaskolski M, Kozak M, Lubkowski J, Palm G, Wlodawer A, Acta Crystallogr D Biol Crystallogr. 2001 Mar;57(Pt 3):369-77. PMID:11223513 Page seeded by OCA on Fri May 2 19:03:35 2008

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