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5bxu
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n4m5== | |
| - | + | <StructureSection load='5bxu' size='340' side='right' caption='[[5bxu]], [[Resolution|resolution]] 1.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5bxu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BXU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4XQ:4,4-PENTANE-1,5-DIYLBIS(1-PROPYL-1H-1,2,3-TRIAZOLE)'>4XQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=GMA:4-AMIDO-4-CARBAMOYL-BUTYRIC+ACID'>GMA</scene></td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bxu OCA], [http://pdbe.org/5bxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bxu RCSB], [http://www.ebi.ac.uk/pdbsum/5bxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bxu ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fischer, G]] | ||
| + | [[Category: Hyvonen, M]] | ||
[[Category: Itzhaki, L]] | [[Category: Itzhaki, L]] | ||
| - | [[Category: Hyvonen, M]] | ||
| - | [[Category: Fischer, G]] | ||
[[Category: Xu, W]] | [[Category: Xu, W]] | ||
| + | [[Category: Ankyrin-repeat domain]] | ||
| + | [[Category: Protein-protein interaction]] | ||
| + | [[Category: Stapled peptide]] | ||
| + | [[Category: Tankyrase]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 10:18, 13 July 2016
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n4m5
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