5hod
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of LHX4 transcription factor complexed with DNA== | |
| - | + | <StructureSection load='5hod' size='340' side='right' caption='[[5hod]], [[Resolution|resolution]] 2.68Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hod]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HOD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hod OCA], [http://pdbe.org/5hod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hod RCSB], [http://www.ebi.ac.uk/pdbsum/5hod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hod ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/LHX4_HUMAN LHX4_HUMAN]] Hypothyroidism due to deficient transcription factors involved in pituitary development or function;Pituitary stalk interruption syndrome;Short stature - pituitary and cerebellar defects - small sella turcica. The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.<ref>PMID:11567216</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LHX4_HUMAN LHX4_HUMAN]] May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Morgunova, E]] | ||
[[Category: Popov, A]] | [[Category: Popov, A]] | ||
| + | [[Category: Taipale, J]] | ||
[[Category: Yin, Y]] | [[Category: Yin, Y]] | ||
| - | [[Category: | + | [[Category: Complex with dna]] |
| - | [[Category: | + | [[Category: Dimer]] |
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription factor]] | ||
Revision as of 18:04, 1 February 2017
Structure of LHX4 transcription factor complexed with DNA
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