1hrn

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[[Image:1hrn.gif|left|200px]]
[[Image:1hrn.gif|left|200px]]
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{{Structure
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|PDB= 1hrn |SIZE=350|CAPTION= <scene name='initialview01'>1hrn</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1hrn", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CHA:1-HYDROXY-2-AMINO-3-CYCLOHEXYLPROPANE'>CHA</scene>, <scene name='pdbligand=CPP:2-CYCLOPROPYLMETHYLENEPROPANAL'>CPP</scene>, <scene name='pdbligand=IP3:1-HYDROXY-3-METHYLBUTANE'>IP3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PPP:3-PHENYL-1,2-PROPANDIOL'>PPP</scene>
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|GENE=
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{{STRUCTURE_1hrn| PDB=1hrn | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hrn OCA], [http://www.ebi.ac.uk/pdbsum/1hrn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hrn RCSB]</span>
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'''HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS'''
'''HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS'''
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[[Category: Anderson, P C.]]
[[Category: Anderson, P C.]]
[[Category: Tong, L.]]
[[Category: Tong, L.]]
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[[Category: aspartic proteinase]]
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[[Category: Aspartic proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:10:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:09:31 2008''
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Revision as of 16:10, 2 May 2008

Image:1hrn.gif

Template:STRUCTURE 1hrn

HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS


Overview

The crystal structures of recombinant glycosylated human renin in complex with several polyhydroxymonoamide inhibitors have been determined at up to 1.8 A resolution. The high resolution structures permit a detailed analysis of the conformation of renin, the interactions between the inhibitors and renin, and the network of ordered water molecules. The polyhydroxymonoamide inhibitors are bound with their backbones in an extended conformation, and with their side-chains occupying the S3 to S1 pockets. The inhibited renin molecules are shown to exist in both the closed and the open conformations. Inhibitors bound to the two distinct forms of renin can assume different conformations at the P3 position.

About this Structure

1HRN is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1HRN with [Pepsin]. Full crystallographic information is available from OCA.

Reference

High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors., Tong L, Pav S, Lamarre D, Pilote L, LaPlante S, Anderson PC, Jung G, J Mol Biol. 1995 Jul 7;250(2):211-22. PMID:7608971 Page seeded by OCA on Fri May 2 19:10:01 2008

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