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5if7
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-279 N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine== | |
| - | + | <StructureSection load='5if7' size='340' side='right' caption='[[5if7]], [[Resolution|resolution]] 2.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5if7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IF7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6AY:N-[(4-CHLOROPHENYL)METHYL]-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>6AY</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4iuj|4iuj]], [[5ieq|5ieq]], [[5if2|5if2]], [[5if5|5if5]], [[5if8|5if8]], [[5ifb|5ifb]], [[5ifc|5ifc]]</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5if7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5if7 OCA], [http://pdbe.org/5if7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5if7 RCSB], [http://www.ebi.ac.uk/pdbsum/5if7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5if7 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PA_I33A0 PA_I33A0]] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Flu]] | ||
| + | [[Category: Fragment screening]] | ||
| + | [[Category: Niaid]] | ||
| + | [[Category: Ssgcid]] | ||
| + | [[Category: Std nmr]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 01:34, 11 March 2017
Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-279 N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Categories: Structural genomic | Flu | Fragment screening | Niaid | Ssgcid | Std nmr | Viral protein
