1hsr

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[[Image:1hsr.gif|left|200px]]
[[Image:1hsr.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1hsr |SIZE=350|CAPTION= <scene name='initialview01'>1hsr</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1hsr", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CA1:Active+Site'>CA1</scene>, <scene name='pdbsite=CA2:Active+Site'>CA2</scene> and <scene name='pdbsite=GL1:Active+Site'>GL1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BHO:BENZHYDROXAMIC+ACID'>BHO</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1hsr| PDB=1hsr | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hsr OCA], [http://www.ebi.ac.uk/pdbsum/1hsr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hsr RCSB]</span>
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}}
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'''BINDING MODE OF BENZHYDROXAMIC ACID TO ARTHROMYCES RAMOSUS PEROXIDASE'''
'''BINDING MODE OF BENZHYDROXAMIC ACID TO ARTHROMYCES RAMOSUS PEROXIDASE'''
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[[Category: Fukuyama, K.]]
[[Category: Fukuyama, K.]]
[[Category: Itakura, H.]]
[[Category: Itakura, H.]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: peroxidase]]
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[[Category: Peroxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:11:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:09:56 2008''
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Revision as of 16:11, 2 May 2008

Image:1hsr.gif

Template:STRUCTURE 1hsr

BINDING MODE OF BENZHYDROXAMIC ACID TO ARTHROMYCES RAMOSUS PEROXIDASE


Overview

The crystal structure of Arthromyces ramosus peroxidase (ARP) in complex with benzhydroxamic acid (BHA) as determined by X-ray analysis at 1.6 A shows unambiguously how BHA binds to ARP. BHA is located in the distal heme pocket. Its functional groups are held by three hydrogen bonds to His56N(epsilon), Arg52N(epsilon), and Pro(154)O, but are too far away to interact with the heme iron. The aromatic ring of BHA is positioned at the entrance of the channel to the heme pocket, approximately parallel to the heme group. Most water molecules at the active site of the native enzyme are replaced by BHA, leaving a ligand, probably a water molecule, at the sixth position of the heme. Results are compared with spectroscopic data.

About this Structure

1HSR is a Single protein structure of sequence from Eukaryota. Full crystallographic information is available from OCA.

Reference

Binding mode of benzhydroxamic acid to Arthromyces ramosus peroxidase shown by X-ray crystallographic analysis of the complex at 1.6 A resolution., Itakura H, Oda Y, Fukuyama K, FEBS Lett. 1997 Jul 21;412(1):107-10. PMID:9257700 Page seeded by OCA on Fri May 2 19:11:51 2008

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OCA

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