1hth

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[[Image:1hth.gif|left|200px]]
[[Image:1hth.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1hth", creates the "Structure Box" on the page.
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{{STRUCTURE_1hth| PDB=1hth | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hth OCA], [http://www.ebi.ac.uk/pdbsum/1hth PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hth RCSB]</span>
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'''THE SOLUTION STRUCTURE OF CYCLIC HUMAN PARATHYROID HORMONE FRAGMENT 1-34, NMR, 10 STRUCTURES'''
'''THE SOLUTION STRUCTURE OF CYCLIC HUMAN PARATHYROID HORMONE FRAGMENT 1-34, NMR, 10 STRUCTURES'''
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[[Category: Schaefer, W.]]
[[Category: Schaefer, W.]]
[[Category: Seidel, G.]]
[[Category: Seidel, G.]]
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[[Category: cyclic]]
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[[Category: Cyclic]]
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[[Category: human parathyroid hormone]]
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[[Category: Human parathyroid hormone]]
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[[Category: nmr structure]]
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[[Category: Nmr structure]]
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[[Category: norleucine]]
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[[Category: Norleucine]]
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[[Category: ornithine]]
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[[Category: Ornithine]]
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Revision as of 16:12, 2 May 2008

Image:1hth.gif

Template:STRUCTURE 1hth

THE SOLUTION STRUCTURE OF CYCLIC HUMAN PARATHYROID HORMONE FRAGMENT 1-34, NMR, 10 STRUCTURES


Overview

Parathyroid hormone-related protein plays a major role in the pathogenesis of humoral hypercalcemia of malignancy. Under normal physiological conditions, parathyroid hormone-related protein is produced in a wide variety of tissues and acts in an autocrine or paracrine fashion. Parathyroid hormone-related protein and parathyroid hormone bind to and activate the same G-protein-coupled receptor. Here we present the structure of the biologically active NH2-terminal domain of human parathyroid hormone-related protein(1-34) in near-physiological solution in the absence of crowding reagents as determined by two-dimensional proton magnetic resonance spectroscopy. An improved strategy for structure calculation revealed the presence of two helices, His-5-Leu-8 and Gln-16-Leu-27, connected by a flexible linker. The parathyroid hormone-related protein(1-34) structure and the structure of human parathyroid hormone(1-37) as well as human parathyroid hormone(1-34) are highly similar, except for the well defined turn, His-14-Ser-17, present in parathyroid hormone. Thus, the similarity of the binding affinities of parathyroid hormone and parathyroid hormone-related protein to their common receptor may be based on their structural similarity.

About this Structure

1HTH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution., Weidler M, Marx UC, Seidel G, Schafer W, Hoffmann E, Esswein A, Rosch P, FEBS Lett. 1999 Feb 12;444(2-3):239-44. PMID:10050767 Page seeded by OCA on Fri May 2 19:12:56 2008

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