1huf

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[[Image:1huf.jpg|left|200px]]
[[Image:1huf.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1huf |SIZE=350|CAPTION= <scene name='initialview01'>1huf</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1huf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= YOPH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])
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|DOMAIN=
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{{STRUCTURE_1huf| PDB=1huf | SCENE= }}
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|RELATEDENTRY=[[1ypt|1YPT]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1huf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1huf OCA], [http://www.ebi.ac.uk/pdbsum/1huf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1huf RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE TYROSINE PHOSPHATASE YOPH FROM YERSINIA PESTIS.'''
'''CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE TYROSINE PHOSPHATASE YOPH FROM YERSINIA PESTIS.'''
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[[Category: Evdokimov, A G.]]
[[Category: Evdokimov, A G.]]
[[Category: Waugh, D S.]]
[[Category: Waugh, D S.]]
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[[Category: beta hairpin]]
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[[Category: Beta hairpin]]
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[[Category: helical bundle]]
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[[Category: Helical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:14:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:10:30 2008''
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Revision as of 16:14, 2 May 2008

Image:1huf.jpg

Template:STRUCTURE 1huf

CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE TYROSINE PHOSPHATASE YOPH FROM YERSINIA PESTIS.


Overview

Yersinia pestis, the causative agent of bubonic plague, injects effector proteins into the cytosol of mammalian cells that enable the bacterium to evade the immune response of the infected organism by interfering with eukaryotic signal transduction pathways. YopH is a modular effector composed of a C-terminal protein tyrosine phosphatase (PTPase) domain and a multifunctional N-terminal domain that not only orchestrates the secretion and translocation of YopH into eukaryotic cells but also binds tyrosine-phosphorylated target proteins to mediate substrate recognition. The crystal structure of the N-terminal domain of YopH (YopH(N); residues 1-130) has been determined at 2.0 A resolution. The amino-acid sequences that target YopH for secretion from the bacterium and translocation into eukaryotic cells form integral parts of this compactly folded domain. The structure of YopH(N) bears no resemblance to eukaryotic phosphotyrosine-binding domains, nor is it reminiscent of any known fold. Residues that have been implicated in phosphotyrosine-dependent protein binding are clustered together on one face of YopH(N), but the structure does not suggest a mechanism for protein-phosphotyrosine recognition.

About this Structure

1HUF is a Single protein structure of sequence from Yersinia pestis. Full crystallographic information is available from OCA.

Reference

Structure of the N-terminal domain of Yersinia pestis YopH at 2.0 A resolution., Evdokimov AG, Tropea JE, Routzahn KM, Copeland TD, Waugh DS, Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):793-9. Epub 2001, May 25. PMID:11375498 Page seeded by OCA on Fri May 2 19:14:23 2008

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