1hup
From Proteopedia
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'''HUMAN MANNOSE BINDING PROTEIN CARBOHYDRATE RECOGNITION DOMAIN TRIMERIZES THROUGH A TRIPLE ALPHA-HELICAL COILED-COIL''' | '''HUMAN MANNOSE BINDING PROTEIN CARBOHYDRATE RECOGNITION DOMAIN TRIMERIZES THROUGH A TRIPLE ALPHA-HELICAL COILED-COIL''' | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sheriff, S.]] | [[Category: Sheriff, S.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:14:51 2008'' | |
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Revision as of 16:14, 2 May 2008
HUMAN MANNOSE BINDING PROTEIN CARBOHYDRATE RECOGNITION DOMAIN TRIMERIZES THROUGH A TRIPLE ALPHA-HELICAL COILED-COIL
Overview
Human mannose-binding protein is a hexamer of trimers with each subunit consisting of an amino-terminal region rich in cysteine, 19 collagen repeats, a 'neck', and a carbohydrate recognition domain that requires calcium to bind ligand. A 148-residue peptide, consisting of the 'neck' and carbohydrate recognition domains forms trimers in solution and in crystals. The structure of this trimeric peptide has been determined in two different crystal forms. The 'neck' forms a triple alpha-helical coiled-coil. Each alpha-helix interacts with a neighbouring carbohydrate recognition domain. The spatial arrangement of the carbohydrate recognition domains suggest how MBP trimers form the basic recognition unit for branched oligosaccharides on microorganisms.
About this Structure
1HUP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil., Sheriff S, Chang CY, Ezekowitz RA, Nat Struct Biol. 1994 Nov;1(11):789-94. PMID:7634089 Page seeded by OCA on Fri May 2 19:14:51 2008
