1hv7

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[[Image:1hv7.jpg|left|200px]]
[[Image:1hv7.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1hv7 |SIZE=350|CAPTION= <scene name='initialview01'>1hv7</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1hv7", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=616:N-[2-(1-FORMYL-2-METHYL-PROPYL)-1-(4-PIPERIDIN-1-YL-BUT-2-ENOYL)-PYRROLIDIN-3-YL]-METHANESULFONAMIDE'>616</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1hv7| PDB=1hv7 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv7 OCA], [http://www.ebi.ac.uk/pdbsum/1hv7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hv7 RCSB]</span>
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}}
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'''PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A'''
'''PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A'''
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[[Category: Singh, O M.]]
[[Category: Singh, O M.]]
[[Category: Skarzynski, T.]]
[[Category: Skarzynski, T.]]
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[[Category: serine protease-inhibitor complex]]
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[[Category: Serine protease-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:15:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:10:54 2008''
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Revision as of 16:15, 2 May 2008

Image:1hv7.jpg

Template:STRUCTURE 1hv7

PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A


Overview

The discovery of a potent intracellular inhibitor of human neutrophil elastase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam development candidate, GW311616A, are described.

About this Structure

1HV7 is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate., Macdonald SJ, Dowle MD, Harrison LA, Shah P, Johnson MR, Inglis GG, Clarke GD, Smith RA, Humphreys D, Molloy CR, Amour A, Dixon M, Murkitt G, Godward RE, Padfield T, Skarzynski T, Singh OM, Kumar KA, Fleetwood G, Hodgson ST, Hardy GW, Finch H, Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8. PMID:11294386 Page seeded by OCA on Fri May 2 19:15:53 2008

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