1hvr

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[[Image:1hvr.gif|left|200px]]
[[Image:1hvr.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1hvr |SIZE=350|CAPTION= <scene name='initialview01'>1hvr</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1hvr", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HYD:HYDROXY+GROUP'>HYD</scene>, <scene name='pdbligand=XK2:[4R-(4ALPHA,5ALPHA,6BETA,7BETA)]-HEXAHYDRO-5,6-DIHYDROXY-1,3-BIS[2-NAPHTHYL-METHYL]-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPIN-2-ONE'>XK2</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1hvr| PDB=1hvr | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hvr OCA], [http://www.ebi.ac.uk/pdbsum/1hvr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hvr RCSB]</span>
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}}
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'''RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS'''
'''RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Chang, C H.]]
[[Category: Chang, C H.]]
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[[Category: hydrolase(acid proteinase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:16:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:11:09 2008''
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Revision as of 16:16, 2 May 2008

Image:1hvr.gif

Template:STRUCTURE 1hvr

RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS


Overview

Mechanistic information and structure-based design methods have been used to design a series of nonpeptide cyclic ureas that are potent inhibitors of human immunodeficiency virus (HIV) protease and HIV replication. A fundamental feature of these inhibitors is the cyclic urea carbonyl oxygen that mimics the hydrogen-bonding features of a key structural water molecule. The success of the design in both displacing and mimicking the structural water molecule was confirmed by x-ray crystallographic studies. Highly selective, preorganized inhibitors with relatively low molecular weight and high oral bioavailability were synthesized.

About this Structure

1HVR is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors., Lam PY, Jadhav PK, Eyermann CJ, Hodge CN, Ru Y, Bacheler LT, Meek JL, Otto MJ, Rayner MM, Wong YN, et al., Science. 1994 Jan 21;263(5145):380-4. PMID:8278812 Page seeded by OCA on Fri May 2 19:16:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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