1hxm
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1hxm.gif|left|200px]] | [[Image:1hxm.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1hxm", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1hxm| PDB=1hxm | SCENE= }} | |
| - | | | + | |
| - | | | + | |
| - | }} | + | |
'''Crystal Structure of a Human Vgamma9/Vdelta2 T Cell Receptor''' | '''Crystal Structure of a Human Vgamma9/Vdelta2 T Cell Receptor''' | ||
| Line 30: | Line 27: | ||
[[Category: Garboczi, D N.]] | [[Category: Garboczi, D N.]] | ||
[[Category: Winter, C C.]] | [[Category: Winter, C C.]] | ||
| - | [[Category: | + | [[Category: Gdtcr]] |
| - | [[Category: | + | [[Category: Ig domain]] |
| - | [[Category: | + | [[Category: T cell receptor]] |
| - | [[Category: | + | [[Category: Tcr]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:20:10 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 16:20, 2 May 2008
Crystal Structure of a Human Vgamma9/Vdelta2 T Cell Receptor
Overview
T-cell antigen receptors composed of gamma and delta polypeptide chains (gammadelta TCRs) can directly recognize antigens in the form of intact proteins or non-peptide compounds, unlike alphabeta TCRs, which recognize antigens bound to major histocompatibility complex molecules (MHC). About 5% of peripheral blood T cells bear gammadelta TCRs, most of which recognize non-peptide phosphorylated antigens. Here we describe the 3.1 A resolution structure of a human gammadelta TCR from a T-cell clone that is phosphoantigen-reactive. The orientation of the variable (V) and constant (C) regions of the gammadelta TCR is unique when compared with alphabeta TCRs or antibodies, and results from an unusually small angle between the Vgamma and Cgamma domains. The complementarity-determining regions (CDRs) of the V domains exhibit a chemically reasonable binding site for phosphorylated antigens, providing a possible explanation for the canonical usage of the Vgamma9 and Vdelta2 gene segments by phosphoantigen-reactive receptors. Although the gammadelta TCR V domains are similar in overall structure to those of alphabeta TCRs, gammadelta TCR C domains are markedly different. Structural differences in Cgamma and Cdelta, and in the location of the disulphide bond between them, may enable gammadelta TCRs to form different recognition/signalling complexes than alphabeta TCRs.
About this Structure
1HXM is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of a human gammadelta T-cell antigen receptor., Allison TJ, Winter CC, Fournie JJ, Bonneville M, Garboczi DN, Nature. 2001 Jun 14;411(6839):820-4. PMID:11459064 Page seeded by OCA on Fri May 2 19:20:10 2008
