1hzi

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[[Image:1hzi.gif|left|200px]]
[[Image:1hzi.gif|left|200px]]
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{{Structure
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|PDB= 1hzi |SIZE=350|CAPTION= <scene name='initialview01'>1hzi</scene>, resolution 2.05&Aring;
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The line below this paragraph, containing "STRUCTURE_1hzi", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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{{STRUCTURE_1hzi| PDB=1hzi | SCENE= }}
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|RELATEDENTRY=[[1rcb|1rcb]], [[2int|2int]], [[1hik|1hik]], [[1hij|1hij]], [[1iar|1iar]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzi OCA], [http://www.ebi.ac.uk/pdbsum/1hzi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hzi RCSB]</span>
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}}
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'''INTERLEUKIN-4 MUTANT E9A'''
'''INTERLEUKIN-4 MUTANT E9A'''
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[[Category: Scheufler, C.]]
[[Category: Scheufler, C.]]
[[Category: 4-helix-bundle]]
[[Category: 4-helix-bundle]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: il-4]]
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[[Category: Il-4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:23:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:12:27 2008''
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Revision as of 16:23, 2 May 2008

Image:1hzi.gif

Template:STRUCTURE 1hzi

INTERLEUKIN-4 MUTANT E9A


Overview

Interleukin 4 (IL-4) is a pleiotropic cytokine which induces T-cell differentiation and class switching of B cells. It therefore plays a central role in the development of allergies and asthma. An IL-4 variant in which Glu9 was mutated to alanine shows an 800-fold drop in binding affinity towards its high-affinity receptor chain. As shown by surface plasmon resonance measurements, this mostly arises from a decreased association rate. Here, the crystal structure of this mutant is reported. It reveals that the protein has a virtually identical structure to the wild type, showing that the unusual behaviour of the mutated protein is not a consequence of misfolding. The possibility that polar interactions in the encounter complex have a steering effect is discussed.

About this Structure

1HZI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation., Hulsmeyer M, Scheufler C, Dreyer MK, Acta Crystallogr D Biol Crystallogr. 2001 Sep;57(Pt 9):1334-6. Epub 2001, Aug 23. PMID:11526337 Page seeded by OCA on Fri May 2 19:23:56 2008

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