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1hzi
From Proteopedia
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[[Image:1hzi.gif|left|200px]] | [[Image:1hzi.gif|left|200px]] | ||
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'''INTERLEUKIN-4 MUTANT E9A''' | '''INTERLEUKIN-4 MUTANT E9A''' | ||
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[[Category: Scheufler, C.]] | [[Category: Scheufler, C.]] | ||
[[Category: 4-helix-bundle]] | [[Category: 4-helix-bundle]] | ||
| - | [[Category: | + | [[Category: Cytokine]] |
| - | [[Category: | + | [[Category: Il-4]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:23:56 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 16:23, 2 May 2008
INTERLEUKIN-4 MUTANT E9A
Overview
Interleukin 4 (IL-4) is a pleiotropic cytokine which induces T-cell differentiation and class switching of B cells. It therefore plays a central role in the development of allergies and asthma. An IL-4 variant in which Glu9 was mutated to alanine shows an 800-fold drop in binding affinity towards its high-affinity receptor chain. As shown by surface plasmon resonance measurements, this mostly arises from a decreased association rate. Here, the crystal structure of this mutant is reported. It reveals that the protein has a virtually identical structure to the wild type, showing that the unusual behaviour of the mutated protein is not a consequence of misfolding. The possibility that polar interactions in the encounter complex have a steering effect is discussed.
About this Structure
1HZI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation., Hulsmeyer M, Scheufler C, Dreyer MK, Acta Crystallogr D Biol Crystallogr. 2001 Sep;57(Pt 9):1334-6. Epub 2001, Aug 23. PMID:11526337 Page seeded by OCA on Fri May 2 19:23:56 2008
