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1i06

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[[Image:1i06.jpg|left|200px]]
[[Image:1i06.jpg|left|200px]]
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{{Structure
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|PDB= 1i06 |SIZE=350|CAPTION= <scene name='initialview01'>1i06</scene>, resolution 1.9&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=TZL:2-(SEC-BUTYL)THIAZOLE'>TZL</scene>
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{{STRUCTURE_1i06| PDB=1i06 | SCENE= }}
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|RELATEDENTRY=[[1mup|1MUP]], [[1io4|1IO4]], [[1io5|1IO5]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i06 OCA], [http://www.ebi.ac.uk/pdbsum/1i06 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i06 RCSB]</span>
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'''CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH SEC-BUTYL-THIAZOLINE'''
'''CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH SEC-BUTYL-THIAZOLINE'''
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[[Category: Timm, D E.]]
[[Category: Timm, D E.]]
[[Category: Zidek, L.]]
[[Category: Zidek, L.]]
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[[Category: beta-barrel]]
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[[Category: Beta-barrel]]
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[[Category: lipocalin]]
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[[Category: Lipocalin]]
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[[Category: pheromone]]
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[[Category: Pheromone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:25:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:12:45 2008''
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Revision as of 16:25, 2 May 2008

Image:1i06.jpg

Template:STRUCTURE 1i06

CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH SEC-BUTYL-THIAZOLINE


Overview

The mouse major urinary proteins are pheromone-binding proteins that function as carriers of volatile effectors of mouse physiology and behavior. Crystal structures of recombinant mouse major urinary protein-I (MUP-I) complexed with the synthetic pheromones, 2-sec-butyl-4,5-dihydrothiazole and 6-hydroxy-6-methyl-3-heptanone, have been determined at high resolution. The purification of MUP-I from mouse liver and a high-resolution structure of the natural isolate are also reported. These results show the binding of 6-hydroxy-6-methyl-3-heptanone to MUP-I, unambiguously define ligand orientations for two pheromones within the MUP-I binding site, and suggest how different chemical classes of pheromones can be accommodated within the MUP-I beta-barrel.

About this Structure

1I06 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of pheromone binding to mouse major urinary protein (MUP-I)., Timm DE, Baker LJ, Mueller H, Zidek L, Novotny MV, Protein Sci. 2001 May;10(5):997-1004. PMID:11316880 Page seeded by OCA on Fri May 2 19:25:15 2008

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