1i1c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1i1c.gif|left|200px]]
[[Image:1i1c.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1i1c |SIZE=350|CAPTION= <scene name='initialview01'>1i1c</scene>, resolution 2.70&Aring;
+
The line below this paragraph, containing "STRUCTURE_1i1c", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1i1c| PDB=1i1c | SCENE= }}
-
|RELATEDENTRY=[[1fc1|1fc1]], [[1i1a|1I1A]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1c OCA], [http://www.ebi.ac.uk/pdbsum/1i1c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i1c RCSB]</span>
+
-
}}
+
'''NON-FCRN BINDING FC FRAGMENT OF RAT IGG2A'''
'''NON-FCRN BINDING FC FRAGMENT OF RAT IGG2A'''
Line 29: Line 26:
[[Category: Jr., A P.West.]]
[[Category: Jr., A P.West.]]
[[Category: Martin, W L.]]
[[Category: Martin, W L.]]
-
[[Category: fc]]
+
[[Category: Fc]]
-
[[Category: igg]]
+
[[Category: Igg]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:27:35 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:13:13 2008''
+

Revision as of 16:27, 2 May 2008

Image:1i1c.gif

Template:STRUCTURE 1i1c

NON-FCRN BINDING FC FRAGMENT OF RAT IGG2A


Overview

The neonatal Fc receptor (FcRn) transports immunoglobulin G (IgG) across epithelia, binding IgG in acidic vesicles (pH < or = 6.5) and releasing IgG in the blood at pH 7.4. Well-ordered FcRn/Fc crystals are prevented by the formation of "oligomeric ribbons" of FcRn dimers bridged by Fc homodimers, thus we crystallized a 1:1 complex between rat FcRn and a heterodimeric Fc containing only one FcRn binding site. The 2.8 A complex structure demonstrates that FcRn uses its alpha2 and beta2-microglobulin domains and carbohydrate to interact with the Fc C(gamma)2-C(gamma)3 interface. The structure reveals conformational changes in Fc and three titratable salt bridges that confer pH-dependent binding, and can be used to guide rational design of therapeutic IgGs with longer serum half-lives.

About this Structure

1I1C is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding., Martin WL, West AP Jr, Gan L, Bjorkman PJ, Mol Cell. 2001 Apr;7(4):867-77. PMID:11336709 Page seeded by OCA on Fri May 2 19:27:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i1c"
Personal tools