1i1e

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1i1e.gif|left|200px]]
[[Image:1i1e.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1i1e |SIZE=350|CAPTION= <scene name='initialview01'>1i1e</scene>, resolution 2.5&Aring;
+
The line below this paragraph, containing "STRUCTURE_1i1e", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=DM2:DOXORUBICIN'>DM2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1i1e| PDB=1i1e | SCENE= }}
-
|RELATEDENTRY=[[1epw|1epw]], [[1f31|1f31]], [[1g9a|1g9a]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1e OCA], [http://www.ebi.ac.uk/pdbsum/1i1e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i1e RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN B COMPLEXED WITH DOXORUBICIN'''
'''CRYSTAL STRUCTURE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN B COMPLEXED WITH DOXORUBICIN'''
Line 29: Line 26:
[[Category: Kumaran, D.]]
[[Category: Kumaran, D.]]
[[Category: Swaminathan, S.]]
[[Category: Swaminathan, S.]]
-
[[Category: botulinum]]
+
[[Category: Botulinum]]
-
[[Category: complex]]
+
[[Category: Complex]]
-
[[Category: doxorubicin]]
+
[[Category: Doxorubicin]]
-
[[Category: metalloprotease]]
+
[[Category: Metalloprotease]]
-
[[Category: neurotoxin]]
+
[[Category: Neurotoxin]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:27:40 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:13:13 2008''
+

Revision as of 16:27, 2 May 2008

Image:1i1e.gif

Template:STRUCTURE 1i1e

CRYSTAL STRUCTURE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN B COMPLEXED WITH DOXORUBICIN


Overview

The neurotoxins of Clostridium botulinum and tetanus bind to gangliosides as a first step of their toxin activity. Identifying suitable receptors that compete with gangliosides could prevent toxin binding to the neuronal cells. A possible ganglioside-binding site of the botulinum neurotoxin B (BoNT/B) has already been proposed and evidence is now presented for a drug binding to botulinum neurotoxin B from structural studies. Doxorubicin, a well known DNA intercalator, binds to the neurotoxin at the receptor-binding site proposed earlier. The structure of the BoNT/B-doxorubicin complex reveals that doxorubicin has interactions with the neurotoxin similar to those of sialyllactose. The aglycone moiety of the doxorubicin stacks with tryptophan 1261 and interacts with histidine 1240 of the binding domain. Here, the possibility is presented of designing a potential antagonist for these neurotoxins from crystallographic analysis of the neurotoxin-doxorubicin complex, which will be an excellent lead compound.

About this Structure

1I1E is a Single protein structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

Reference

Crystallographic evidence for doxorubicin binding to the receptor-binding site in Clostridium botulinum neurotoxin B., Eswaramoorthy S, Kumaran D, Swaminathan S, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1743-6. Epub 2001, Oct 25. PMID:11679763 Page seeded by OCA on Fri May 2 19:27:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i1e"
Personal tools