1i1i

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[[Image:1i1i.gif|left|200px]]
[[Image:1i1i.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1i1i |SIZE=350|CAPTION= <scene name='initialview01'>1i1i</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1i1i", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Neurolysin Neurolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.16 3.4.24.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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{{STRUCTURE_1i1i| PDB=1i1i | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1i OCA], [http://www.ebi.ac.uk/pdbsum/1i1i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i1i RCSB]</span>
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'''NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE'''
'''NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE'''
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[[Category: Rodgers, D W.]]
[[Category: Rodgers, D W.]]
[[Category: Tolbert, W D.]]
[[Category: Tolbert, W D.]]
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[[Category: endopeptidase]]
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[[Category: Endopeptidase]]
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[[Category: neuropeptidase]]
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[[Category: Neuropeptidase]]
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[[Category: zinc metallopeptidase]]
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[[Category: Zinc metallopeptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:27:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:13:16 2008''
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Revision as of 16:27, 2 May 2008

Image:1i1i.gif

Template:STRUCTURE 1i1i

NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE


Overview

The zinc metallopeptidase neurolysin is shown by x-ray crystallography to have large structural elements erected over the active site region that allow substrate access only through a deep narrow channel. This architecture accounts for specialization of this neuropeptidase to small bioactive peptide substrates without bulky secondary and tertiary structures. In addition, modeling studies indicate that the length of a substrate N-terminal to the site of hydrolysis is restricted to approximately 10 residues by the limited size of the active site cavity. Some structural elements of neurolysin, including a five-stranded beta-sheet and the two active site helices, are conserved with other metallopeptidases. The connecting loop regions of these elements, however, are much extended in neurolysin, and they, together with other open coil elements, line the active site cavity. These potentially flexible elements may account for the ability of the enzyme to cleave a variety of sequences.

About this Structure

1I1I is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of neurolysin reveals a deep channel that limits substrate access., Brown CK, Madauss K, Lian W, Beck MR, Tolbert WD, Rodgers DW, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3127-32. Epub 2001 Mar 6. PMID:11248043 Page seeded by OCA on Fri May 2 19:27:53 2008

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