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1i27

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[[Image:1i27.gif|left|200px]]
[[Image:1i27.gif|left|200px]]
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{{Structure
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|GENE= RAP74 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1i27| PDB=1i27 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i27 OCA], [http://www.ebi.ac.uk/pdbsum/1i27 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i27 RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)'''
'''CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)'''
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[[Category: Kamada, K.]]
[[Category: Kamada, K.]]
[[Category: Roeder, R G.]]
[[Category: Roeder, R G.]]
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[[Category: general transcription factor]]
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[[Category: General transcription factor]]
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[[Category: rap30]]
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[[Category: Rap30]]
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[[Category: rap74]]
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[[Category: Rap74]]
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[[Category: rna polymerase ii]]
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[[Category: Rna polymerase ii]]
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[[Category: tfiif]]
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[[Category: Tfiif]]
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[[Category: winged-helix domain]]
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[[Category: Winged-helix domain]]
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Revision as of 16:29, 2 May 2008

Image:1i27.gif

Template:STRUCTURE 1i27

CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)


Overview

The x-ray structure of a C-terminal fragment of the RAP74 subunit of human transcription factor (TF) IIF has been determined at 1.02-A resolution. The alpha/beta structure is strikingly similar to the globular domain of linker histone H5 and the DNA-binding domain of hepatocyte nuclear factor 3gamma (HNF-3gamma), making it a winged-helix protein. The surface electrostatic properties of this compact domain differ significantly from those of bona fide winged-helix transcription factors (HNF-3gamma and RFX1) and from the winged-helix domains found within the RAP30 subunit of TFIIF and the beta subunit of TFIIE. RAP74 has been shown to interact with the TFIIF-associated C-terminal domain phosphatase FCP1, and a putative phosphatase binding site has been identified within the RAP74 winged-helix domain.

About this Structure

1I27 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the C-terminal domain of the RAP74 subunit of human transcription factor IIF., Kamada K, De Angelis J, Roeder RG, Burley SK, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3115-20. PMID:11248041 Page seeded by OCA on Fri May 2 19:29:08 2008

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